Mostrar el registro sencillo del ítem

dc.contributor.author
Lores Arnaiz, Silvia  
dc.contributor.author
Lombardi, Paulina  
dc.contributor.author
Karadayian, Analia Graciela  
dc.contributor.author
Orgambide, Federico Oscar  
dc.contributor.author
Cicerchia, Daniela Griselda  
dc.contributor.author
Bustamante, Juanita  
dc.date.available
2018-03-15T18:51:22Z  
dc.date.issued
2016-01  
dc.identifier.citation
Lores Arnaiz, Silvia; Lombardi, Paulina; Karadayian, Analia Graciela; Orgambide, Federico Oscar; Cicerchia, Daniela Griselda; et al.; Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging; Springer/Plenum Publishers; Neurochemical Research; 41; 1-2; 1-2016; 353-363  
dc.identifier.issn
0364-3190  
dc.identifier.uri
http://hdl.handle.net/11336/38972  
dc.description.abstract
Alterations in mitochondrial bioenergetics have been associated with brain aging. In order to evaluate the susceptibility of brain cortex synaptosomes and non-synaptic mitochondria to aging-dependent dysfunction, male Swiss mice of 3 or 17 months old were used. Mitochondrial function was evaluated by oxygen consumption, mitochondrial membrane potential and respiratory complexes activity, together with UCP-2 protein expression. Basal respiration and respiration driving proton leak were decreased by 26 and 33 % in synaptosomes from 17-months old mice, but spare respiratory capacity was not modified by aging. Succinate supported state 3 respiratory rate was decreased by 45 % in brain cortex non-synaptic mitochondria from 17-month-old mice, as compared with young animals, but respiratory control was not affected. Synaptosomal mitochondria would be susceptible to undergo calcium-induced depolarization in 17 months-old mice, while non-synaptic mitochondria would not be affected by calcium overload. UCP-2 was significantly upregulated in both synaptosomal and submitochondrial membranes from 17-months old mice, compared to young animals. UCP-2 upregulation seems to be a possible mechanism by which mitochondria would be resistant to suffer oxidative damage during aging.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer/Plenum Publishers  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Aging  
dc.subject
Cerebral Cortex  
dc.subject
Depolarization  
dc.subject
Non-Synaptic Mitochondria  
dc.subject
Respiration  
dc.subject
Synaptosomes  
dc.subject.classification
Otras Ciencias de la Salud  
dc.subject.classification
Ciencias de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-14T17:12:49Z  
dc.identifier.eissn
1573-6903  
dc.journal.volume
41  
dc.journal.number
1-2  
dc.journal.pagination
353-363  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Lores Arnaiz, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina  
dc.description.fil
Fil: Lombardi, Paulina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina  
dc.description.fil
Fil: Karadayian, Analia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina  
dc.description.fil
Fil: Orgambide, Federico Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina  
dc.description.fil
Fil: Cicerchia, Daniela Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina  
dc.description.fil
Fil: Bustamante, Juanita. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina  
dc.journal.title
Neurochemical Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11064-015-1817-5  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11064-015-1817-5