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dc.contributor.author
Reig, Ramon
dc.contributor.author
Zerlaut, Yann
dc.contributor.author
Vergara, Ramiro Oscar
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Destexhe, Alain
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Sánchez Vives, María V.
dc.date.available
2018-03-07T19:06:16Z
dc.date.issued
2015-02
dc.identifier.citation
Reig, Ramon; Zerlaut, Yann; Vergara, Ramiro Oscar; Destexhe, Alain; Sánchez Vives, María V.; Gain modulation of synaptic inputs by network state in auditory cortex in vivo; Society for Neuroscience; Journal of Neuroscience; 35; 6; 2-2015; 2689-2702
dc.identifier.issn
0270-6474
dc.identifier.uri
http://hdl.handle.net/11336/38163
dc.description.abstract
The cortical network recurrent circuitry generates spontaneous activity organized into Up (active) and Down (quiescent) states during slow-wave sleep or anesthesia. These different states of cortical activation gain modulate synaptic transmission. However, the reported modulation that Up states impose on synaptic inputs is disparate in the literature, including both increases and decreases of responsiveness. Here, we tested the hypothesis that such disparate observations may depend on the intensity of the stimulation. By means of intracellular recordings, we studied synaptic transmission during Up and Down states in rat auditory cortex in vivo. Synaptic potentials were evoked either by auditory or electrical (thalamocortical, intracortical) stimulation while randomly varying the intensity of the stimulus. Synaptic potentials evoked by the same stimulus intensity were compared in Up/Down states. Up states had a scaling effect on the stimulus-evoked synaptic responses: the amplitude of weaker responses was potentiated whereas that of larger responses was maintained or decreased with respect to the amplitude during Down states. We used a computational model to explore the potential mechanisms explaining this nontrivial stimulus–response relationship. During Up/Down states, there is different excitability in the network and the neuronal conductance varies. We demonstrate that the competition between presynaptic recruitment and the changing conductance might be the central mechanism explaining the experimentally observed stimulus–response relationships. We conclude that the effect that cortical network activation has on synaptic transmission is not constant but contingent on the strength of the stimulation, with a larger modulation for stimuli involving both thalamic and cortical networks.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for Neuroscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Cerebral Cortex
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Computational Model
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Oscillations
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Synaptic Inputs
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Thalamocortical
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Up States
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Gain modulation of synaptic inputs by network state in auditory cortex in vivo
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-06T17:44:56Z
dc.journal.volume
35
dc.journal.number
6
dc.journal.pagination
2689-2702
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington, DC
dc.description.fil
Fil: Reig, Ramon. Institut d'Investigacions Biomèdiques August Pi i Sunyer; España. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
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Fil: Zerlaut, Yann. Centre National de la Recherche Scientifique; Francia. Unité de Neurosciences, Information et Complexité; Francia
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Fil: Vergara, Ramiro Oscar. Institut d'Investigacions Biomèdiques August Pi i Sunyer; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Acústica y Percepción Sonora; Argentina
dc.description.fil
Fil: Destexhe, Alain. Centre National de la Recherche Scientifique; Francia. Unité de Neurosciences, Information et Complexité; Francia
dc.description.fil
Fil: Sánchez Vives, María V.. Institut d'Investigacions Biomèdiques August Pi i Sunyer; España. Institució Catalana de Recerca i Estudis Avancats; España
dc.journal.title
Journal of Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1523/JNEUROSCI.2004-14.2015
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/35/6/2689/tab-article-info
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