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dc.contributor.author
Accialini, Paula Lucia
dc.contributor.author
Irusta, Griselda
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Bechis, Andrés
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Bas, Diana Ester
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Parborell, Maria Fernanda Agustina
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Abramovich, Dalhia Nurit
dc.contributor.author
Tesone, Marta
dc.date.available
2018-02-11T23:55:39Z
dc.date.issued
2017-08
dc.identifier.citation
Accialini, Paula Lucia; Irusta, Griselda; Bechis, Andrés; Bas, Diana Ester; Parborell, Maria Fernanda Agustina; et al.; Tankyrase inhibition regulates corpus luteum development and luteal function in gonadotropin-treated rats; Wiley-liss, Div John Wiley & Sons Inc; Molecular Reproduction and Development; 84; 8; 8-2017; 719-730
dc.identifier.issn
1040-452X
dc.identifier.uri
http://hdl.handle.net/11336/36417
dc.description.abstract
Tankyrases are physiological regulators of Axin, a protein involved in several cellular processes, including Wnt signaling. Here, we investigated the effect of a specific Tankyrase inhibitor (XAV939) in follicular-luteal dynamics, and its possible relationship with ovarian vascular development. Studies were designed to analyze the effect of intrabursa administration of XAV939 in gonadotropin-treated prepubertal rats. In particular, we examined follicle and corpus luteum development, steroidogenesis, angiogenic markers, and apoptotic parameters. We found that in vivo inhibition of Wnt signaling impaired corpus luteum development, with a decrease in the number of corpora lutea balanced by a high number of cysts; decreased circulating progesterone levels, likely due to a decrease in Steroidogenic acute regulatory protein content in the corpus luteum; and increased pro-apoptotic parameters. In addition, Extracellular signal-regulated kinase phosphorylation, Vascular endothelium growth factor 120 content, and endothelial cell area were diminished in corpora lutea of inhibitor-treated ovaries. Thus, Wnt/β-catenin signaling appears to participate in the regulation of corpus luteum development and luteal cell function.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/embargoedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Luteinization
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Progesterone
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Steroidogenesis
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Tankyrase Inhibitor
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Wnt/Β-Catenin
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Tankyrase inhibition regulates corpus luteum development and luteal function in gonadotropin-treated rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-02-05T13:42:31Z
dc.identifier.eissn
1098-2795
dc.journal.volume
84
dc.journal.number
8
dc.journal.pagination
719-730
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.conicet.avisoEditorial
This is the pre-peer reviewed version of the following article: Accialini,Paula et al. Tankyrase inhibition regulates corpus luteum development and luteal function in gonadotropin-treated rats. Molecular reproduction and development, 2017. 84(8):719-730, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/mrd.22853/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.description.fil
Fil: Accialini, Paula Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Irusta, Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Bechis, Andrés. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Bas, Diana Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Parborell, Maria Fernanda Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Abramovich, Dalhia Nurit. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Tesone, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.journal.title
Molecular Reproduction and Development
dc.rights.embargoDate
2018-09-01
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/mrd.22853/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/mrd.22853
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/28628258
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