Mostrar el registro sencillo del ítem
dc.contributor.author
Barbosa, Jahamunna A.
dc.contributor.author
Zoppi, Ariana
dc.contributor.author
Quevedo, Mario Alfredo
dc.contributor.author
de Melo, Polyanne
dc.contributor.author
de Medeiros, Arthur S. A
dc.contributor.author
Streck, Leticia
dc.contributor.author
de Oliveira, Alice R.
dc.contributor.author
Fernandes Pedrosa, Matheus F.
dc.contributor.author
Longhi, Marcela Raquel
dc.contributor.author
da Silva Junior, Arnobio A.
dc.date.available
2018-01-17T14:24:46Z
dc.date.issued
2014-05
dc.identifier.citation
de Oliveira, Alice R.; Zoppi, Ariana; de Melo, Polyanne; de Medeiros, Arthur S. A; Streck, Leticia; da Silva Junior, Arnobio A.; et al.; Triethanolamine Stabilization of Methotrexate-β-Cyclodextrin Interactions in Ternary Complexes; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 15; 9; 5-2014; 17077-17099
dc.identifier.issn
1422-0067
dc.identifier.uri
http://hdl.handle.net/11336/33583
dc.description.abstract
The interaction of methotrexate (MTX) with beta-cyclodextrin (β-CD) in the presence of triethanolamine (TEA) was investigated with the aim to elucidate the mechanism whereby self-assembly cyclodextrin systems work in association with this third component. Solubility diagram studies showed synergic increment of the MTX solubility to be about thirty-fold. Experiments using 2D ROESY and molecular modeling studies revealed the inclusion of aromatic ring III of the drug into β-CD cavity, in which TEA contributes by intensifying MTX interaction with β-CD and stabilizes MTX:β-CD:TEA ternary complex by electrostatic interaction. The maintenance of these interactions in solid phase was also studied in ternary MTX:β-CD:TEA and comparisons were made with freeze dried binary MTX:β-CD and physical mixtures. FTIR studies evidenced that MTX–β-CD interaction remained in solid ternary complexes, which was also supported by thermal (differential scanning calorimetry (DSC), thermogravimetric analysis (TG)/first derivative of TG analysis (DTG) and C,N,H elementary analysis) and structural (X-ray diffraction analysis, (XRD)) studies, mainly regarding the increment of drug stability. The efficient in vitro drug dissolution studies successfully demonstrated the contribution of ternary complexes, which highlights the importance of this possible new raw material for further applications in drug delivery systems
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Molecular Diversity Preservation International
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Methotrexate
dc.subject
Cyclodextrin
dc.subject
Inclusion Complexes
dc.subject
Ternary Complexes
dc.subject
Drug Delivery Systems
dc.subject.classification
Nano-materiales
dc.subject.classification
Nanotecnología
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Triethanolamine Stabilization of Methotrexate-β-Cyclodextrin Interactions in Ternary Complexes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-03T20:13:33Z
dc.journal.volume
15
dc.journal.number
9
dc.journal.pagination
17077-17099
dc.journal.pais
Suiza
dc.journal.ciudad
Basel
dc.description.fil
Fil: Barbosa, Jahamunna A.. Universidade Federal do Rio Grande do Norte; Brasil
dc.description.fil
Fil: Zoppi, Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Quevedo, Mario Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: de Melo, Polyanne. Universidade Federal do Rio Grande do Norte; Brasil
dc.description.fil
Fil: de Medeiros, Arthur S. A. Universidade Federal do Rio Grande do Norte; Brasil
dc.description.fil
Fil: Streck, Leticia. Universidade Federal do Rio Grande do Norte; Brasil
dc.description.fil
Fil: de Oliveira, Alice R.. Universidade Federal do Rio Grande do Norte; Brasil
dc.description.fil
Fil: Fernandes Pedrosa, Matheus F.. Universidade Federal do Rio Grande do Norte; Brasil
dc.description.fil
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: da Silva Junior, Arnobio A.. Universidade Federal do Rio Grande do Norte; Brasil
dc.journal.title
International Journal of Molecular Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ijms150917077
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1422-0067/15/9/17077
Archivos asociados