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dc.contributor.author
Rocha Viegas, Luciana
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Villa, Raffaella
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Gutierrez, Arantxa
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Iriondo, Oihana
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Shiekhattar, Ramin
dc.contributor.author
Di Croce, Luciano
dc.date.available
2018-01-15T21:30:24Z
dc.date.issued
2014-10
dc.identifier.citation
Rocha Viegas, Luciana; Shiekhattar, Ramin; Di Croce, Luciano; Iriondo, Oihana; Gutierrez, Arantxa; Villa, Raffaella; et al.; Role of UTX in Retinoic Acid Receptor-Mediated Gene Regulation in Leukemia; American Society for Microbiology; Molecular and Cellular Biology; 34; 19; 10-2014; 3765-3775
dc.identifier.issn
0270-7306
dc.identifier.uri
http://hdl.handle.net/11336/33373
dc.description.abstract
Human UTX, a member of the Jumonji C family of proteins, associates with mixed-lineage leukemia 3/4 complexes. Stimulation with retinoic acid leads to the recruitment of UTX-containing complexes to HOX genes, which results in demethylation of histone H3 lysine 27 and concomitant methylation of histone H3 lysine 4. Here, we show that UTX interacts with the retinoic acid receptor α (RARα) and that this interaction is essential for proper differentiation of leukemic U937 cells in response to retinoic acid. UTX occupies the promoters of several RAR target genes and regulates their transcriptional output by modulating ASH2L complex recruitment. Overexpression of UTX in promyelocytic NB4 cells results in enhanced cellular differentiation upon retinoic acid treatment. Our results show that UTX is important for RAR-mediated transcription and provide insight into the critical role of cross talk between histone H3 lysine 4 methylation and histone H3 lysine 27 demethylation during cellular differentiation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Microbiology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Utx
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Rar
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Leukemia
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Differentiation
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Role of UTX in Retinoic Acid Receptor-Mediated Gene Regulation in Leukemia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-12T19:47:34Z
dc.journal.volume
34
dc.journal.number
19
dc.journal.pagination
3765-3775
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Rocha Viegas, Luciana. Center for Genomic Regulation; España. Universitat Pompeu Fabra; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Villa, Raffaella. Center for Genomic Regulation; España. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Gutierrez, Arantxa. Center for Genomic Regulation; España. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Iriondo, Oihana. Center for Genomic Regulation; España. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Shiekhattar, Ramin. University of Miami; Estados Unidos
dc.description.fil
Fil: Di Croce, Luciano. Center for Genomic Regulation; España. Universitat Pompeu Fabra; España. Institució Catalana de Recerca i Estudis Avancats; España
dc.journal.title
Molecular and Cellular Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/MCB.00839-14
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://mcb.asm.org/content/34/19/3765
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