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dc.contributor.author
Castro, Jose Alberto
dc.contributor.author
Montalto, Maria
dc.contributor.author
Fanelli, Silvia Laura
dc.contributor.author
Cignoli de Ferreyra, Elida
dc.contributor.author
Diaz, Edith Graciela
dc.contributor.author
Castro, Jose Alberto
dc.date.available
2018-01-08T21:10:14Z
dc.date.issued
2003-09
dc.identifier.citation
Castro, Jose Alberto; Montalto, Maria; Fanelli, Silvia Laura; Cignoli de Ferreyra, Elida; Diaz, Edith Graciela; et al.; Benznidazole-induced ultrastructural and biochemical alterations in rat esophagus; Elsevier Ireland; Toxicology; 191; 2-3; 9-2003; 189-198
dc.identifier.issn
0300-483X
dc.identifier.uri
http://hdl.handle.net/11336/32597
dc.description.abstract
Benznidazole (Bz) is a drug used in the chemotherapy of the acute and intermediate phases of Chagas’ disease (American Trypanosomiasis), an endemic parasitic disease afflicting more than 16 million people in Latin America. Serious toxic side effects of Bz have been reported in treated human beings and in experimental animals. Bz toxicity would be linked to its nitroreductive bioactivation to reactive intermediates and to the corresponding amine known to occur in vivo and mediated by different enzymatic systems. In the present study the presence of Bz nitroreductases in rat esophagus and the occurrence of Bz induced esophageal cell injury are described. Already 1 and 3 h after an intragastric Bz administration to Sprague–Dawley male rats (240–260 g body weight) at a dose of 100 mg/kg esophageal levels of the drug were 66.4±4.0 and 149.2±14.3 nmol per g tissue, respectively. The esophageal mucosa homogenates exhibited Bz nitroreductase activity attributable to the participation of cytochrome P450 reductase and xanthine oxidoreductase (XOR). The ultrastructural observation of esophageal tissue from Bz treated animals 24 h after its administration evidenced: detachment and conglomeration of polyribosomes, reduction in the presence of desmosomes and of the amount of bacteria on its surface. The potential significance of these alterations is not fully clear at present. However, these deleterious effects might be additive or synergistic with those induced by the evolution of the disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Benznidazole
dc.subject
Chagas Disease
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Toxic Side Effects
dc.subject.classification
Toxicología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Benznidazole-induced ultrastructural and biochemical alterations in rat esophagus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-12T20:03:33Z
dc.journal.volume
191
dc.journal.number
2-3
dc.journal.pagination
189-198
dc.journal.pais
Irlanda
dc.description.fil
Fil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Montalto, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
dc.description.fil
Fil: Fanelli, Silvia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
dc.description.fil
Fil: Cignoli de Ferreyra, Elida. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
dc.description.fil
Fil: Diaz, Edith Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
dc.journal.title
Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0300483X03002622
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/S0300-483X(03)00262-2
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