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dc.contributor.author
Aloisio, Carolina
dc.contributor.author
Oliveira, Anselmo Gomes de
dc.contributor.author
Longhi, Marcela Raquel
dc.date.available
2018-01-04T18:17:16Z
dc.date.issued
2014-07
dc.identifier.citation
Longhi, Marcela Raquel; Oliveira, Anselmo Gomes de; Aloisio, Carolina; Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 100; 7-2014; 64-73
dc.identifier.issn
0731-7085
dc.identifier.uri
http://hdl.handle.net/11336/32330
dc.description.abstract
This study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with β-(βCD), methyl-(MβCD) and hydroxypropyl-β-cyclodextrin (HPβCD) using meglumine (MEG) as the ternary component. The combination of MEG with MβCD resulted the best approach, with an increased effect (29-fold) of the aqueous solubility of SMR. The mode of inclusion was supported by 2D NMR, which indicated that real ternary complexes were formed between SMR, MEG and MβCD or HPβCD. Solid state analysis was performed using Fourier-transform infrared spectroscopy (FT IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD), which demonstrated that different interactions occurred among SMR, MEG and MβCD or HPβCD in the ternary lyophilized systems. The ternary complexes with βCD and MβCD produced an additional retention effect on the release of SMR compared to the corresponding binary complexes, implying that they were clearly superior in terms of solubility and release modulation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Sulfamerazine
dc.subject
Cyclodextrin
dc.subject
Ternary Complexes
dc.subject
Solubility
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Nano-materiales
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-03T20:09:28Z
dc.journal.volume
100
dc.journal.pagination
64-73
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Aloisio, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Oliveira, Anselmo Gomes de. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.journal.title
Journal of Pharmaceutical and Biomedical Analysis
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jpba.2014.07.008
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S073170851400329X
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