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dc.contributor.author
Katz, Maximiliano Javier
dc.contributor.author
Simonetta, Sergio Hernan
dc.contributor.author
Ralph, Martin R.
dc.contributor.author
Golombek, Diego Andrés
dc.date.available
2017-11-30T19:16:42Z
dc.date.issued
2008-10
dc.identifier.citation
Katz, Maximiliano Javier; Simonetta, Sergio Hernan; Ralph, Martin R.; Golombek, Diego Andrés; Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light; Elsevier; Pharmacology Biochemistry and Behavior; 90; 4; 10-2008; 763-768
dc.identifier.issn
0091-3057
dc.identifier.uri
http://hdl.handle.net/11336/29378
dc.description.abstract
PP2B is a Ca2+/calmodulin-dependent protein phosphatase that is ubiquitously expressed in mammals. Among other actions, it is an effector mechanism in NMDA-mediated glutamate neurotransmission as well as a regulator of GSK3beta and MAPK signaling cascades. Because all of these mechanisms have demonstrable roles in the control of circadian rhythyms, we hypothesized that PP2B would be a key regulator of rhythm generation and entrainment, and that through inhibition of its phosphatase activity, the circadian system would be affected by immunosuppressant drug therapy. We report here that immunosuppressant drugs (cyclosporin A, FK506) (1) block the circadian responses to light that underlie photic entrainment; (2) produce circadian phase shifts with a characteristic nonphotic profile; and (3) disrupt circadian rhythm expression when applied chronically. These results indicate a role for PP2B in circadian rhythm generation and entrainment. In addition, because rhythm disturbance has been implicated in impairment of both physical and mental health, we suggest that the use of immunosuppressants would be safer and more efficacious if their impacts on circadian rhythmicity were taken into account
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Calcineurin
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Tacrolimus
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Circadian
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Entrainment
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Cyclosporin A
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-11-16T15:14:22Z
dc.identifier.eissn
1873-5177
dc.journal.volume
90
dc.journal.number
4
dc.journal.pagination
763-768
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Tarrytown
dc.description.fil
Fil: Katz, Maximiliano Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Nacional de Quilmes; Argentina
dc.description.fil
Fil: Simonetta, Sergio Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Nacional de Quilmes; Argentina
dc.description.fil
Fil: Ralph, Martin R.. University of Toronto; Canadá
dc.description.fil
Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes; Argentina
dc.journal.title
Pharmacology Biochemistry and Behavior
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0091305708002074
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.pbb.2008.05.017
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