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dc.contributor.author
Checa Cabot, Claudia A.
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Stoszek, Sonia K.
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Quarleri, Jorge Fabian
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Losso, Marcelo H.
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Ivalo, Silvina
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Peixoto, Mario F.
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Pilotto, José H.
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Salomon, Horacio Eduardo
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Sidi, Leon C.
dc.contributor.author
Read, Jennifer
dc.date.available
2017-10-18T20:33:23Z
dc.date.issued
2013-12
dc.identifier.citation
Checa Cabot, Claudia A.; Stoszek, Sonia K.; Quarleri, Jorge Fabian; Losso, Marcelo H.; Ivalo, Silvina; et al.; Mother-to-Child transmission of HCV among HIV/HCV Co-infected women; Oxford University Press; Journal of the Pediatrics Infectious Diseases Society; 2; 2; 12-2013; 126-135
dc.identifier.issn
2048-7193
dc.identifier.uri
http://hdl.handle.net/11336/26788
dc.description.abstract
BACKGROUND: Maternal human immunodeficiency virus (HIV) coinfection has been associated with increased hepatitis C virus (HCV) mother-to-child transmission (MTCT). We hypothesized that HCV/HIV-coinfected women with well-controlled HIV disease would not have increased HCV MTCT. METHODS: The NISDI Perinatal and LILAC cohorts enrolled HIV-infected pregnant women and their infants in Latin America and the Caribbean. This substudy evaluated the HCV infection status of mothers at participating sites and their live born, singleton infants who had a 6-month postnatal visit by December 31, 2008. Mothers who were anti-HCV-positive, or who had CD4 counts (cells/mm(3)) <200 with detectable HCV RNA, were considered HCV-infected. All HCV-infected women were tested for HCV RNA. Infants with HCV RNA were considered HCV-infected. RESULTS: Of 1042 enrolled women, 739 (71%) mother-infant pairs met the inclusion criteria. Of the 739 women, 67 (9%) were anti-HCV-positive and 672 anti-HCV-negative [68 (10%) with CD4 counts <200; of these, 3 (4.4%) were HCV RNA-positive]. Therefore, our study population comprised 70 HCV-infected (47 with HCV RNA) and 669 HCV-uninfected women (and their infants). Factors associated with maternal HCV infection included unemployment (odds ratio [OR] = 2.58); tobacco (OR = 1.73) or marijuana (OR = 3.88) use during pregnancy; enrollment HIV viral load ([VL] copies/mL) ≥10 000 (OR = 2.27); HIV clinical disease stage C (OR = 2.12); and abnormal alanine aminotransferase (OR = 4.24) or aspartate aminotransferase (OR = 11.98). Four of 47 infants (8.5%) born to HCV-viremic women were HCV-infected, and all 4 mothers had HIV VL <1000 at hospital discharge after delivery. CONCLUSIONS: HCV MTCT among HIV/HCV-coinfected women with well-controlled HIV disease may be lower than reported in other coinfected populations. Studies with longer infant follow-up are needed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Mother-To-Child Transmission
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Hcv
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Hiv/Hcv Co-Infection
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Ética Médica
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Mother-to-Child transmission of HCV among HIV/HCV Co-infected women
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2015-08-14T18:18:05Z
dc.identifier.eissn
2048-7207
dc.journal.volume
2
dc.journal.number
2
dc.journal.pagination
126-135
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Checa Cabot, Claudia A.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
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Fil: Stoszek, Sonia K.. Westat; Estados Unidos
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Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
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Fil: Losso, Marcelo H.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
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Fil: Ivalo, Silvina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
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Fil: Peixoto, Mario F.. Hospital Femina. Vertical Transmission Prevention Unit; Brasil
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Fil: Pilotto, José H.. Hospital Geral de Nova Iguaçu and Laboratorio de AIDS e Imunologia Molecular; Brasil
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Fil: Salomon, Horacio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
dc.description.fil
Fil: Sidi, Leon C.. Hospital Federal dos Servidores do Estado; Brasil
dc.description.fil
Fil: Read, Jennifer. National Institutes of Health; Estados Unidos
dc.journal.title
Journal of the Pediatrics Infectious Diseases Society
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jpids/article-lookup/doi/10.1093/jpids/pis091
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/0.1093/jpids/pis091
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502757/
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