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dc.contributor.author
Velasquez, Ethel V.
dc.contributor.author
Rios, Mariana
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Ortiz, María Elena
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Lizama, Carlos
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Nuñez, Elizabeth
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Abramovich, Dalhia Nurit
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Orge, Felipe
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Oliva, Bárbara
dc.contributor.author
Orellana, Renán
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Villalon, Manuel
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Moreno, Ricardo D.
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Tesone, Marta
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Rokka, Anne
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Corthals, Garry
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Croxatto, Horacio B.
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Parborell, Maria Fernanda Agustina
dc.contributor.author
Owen, Gareth I.
dc.date.available
2015-10-08T19:51:36Z
dc.date.issued
2013-03-20
dc.identifier.citation
Velasquez, Ethel V.; Rios, Mariana; Ortiz, María Elena; Lizama, Carlos; Nuñez, Elizabeth; et al.; Concanavalin-A induces granulosa cell death and inhibits fsh-mediated follicular growth and ovarian maturation in female rats; Endocrine Society; Endocrinology; 154; 5; 20-3-2013; 1885-1896
dc.identifier.issn
0013-7227
dc.identifier.uri
http://hdl.handle.net/11336/2438
dc.description.abstract
Reproductive success stems from a finely regulated balance between follicular maturation and atresia, in which the role of carbohydrate structure is poorly understood. Here, we describe for the first time a fraction of purified recombinant human FSH that is capable of bringing about the cell death of granulosa cells and preventing follicular maturation in a rat model. Further analysis by mass spectrometry revealed the presence of the lectin Concanavalin-A (Con-A) within this fraction of recombinant FSH. Using both the fractionated FSH and Con-A, the observed cell death was predominantly located to the granulosa cells. Ex vivo culture of rat follicles demonstrated that follicle degeneration occurred and resulted in the release of a denuded and deteriorated oocyte. Moreover, in vivo experiments confirmed an increase in atresia and a corresponding reduction confined to follicle in early antral stage. As a mechanism of action, Con-A reduces ovarian proliferation, Von Willebrand staining, and angiogenesis. Based on the observation that Con-A may induce granulosa cell death followed by follicle death, our results further demonstrate that follicular carbohydrate moiety is changing under the influence of FSH, which may allow a carbohydrate- binding lectin to increase granulosa cell death. The physiological consequences of circulating lectin-like molecules remain to be determined. However, our results suggest a potential exploitation of carbohydrate binding in fertility and ovarian cancer treatment. This work may shed light on a key role of carbohydrates in the still obscure physiological process of follicular selection and atresia.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Endocrine Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Concanavalin A
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Granulosa Cells
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Apoptosis
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Fsh
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Concanavalin-A induces granulosa cell death and inhibits fsh-mediated follicular growth and ovarian maturation in female rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
1945-7170
dc.journal.volume
154
dc.journal.number
5
dc.journal.pagination
1885-1896
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Velasquez, Ethel V.. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Rios, Mariana. Pontificia Universidad Católica de Chile; Chile
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Fil: Ortiz, María Elena. Pontificia Universidad Católica de Chile; Chile
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Fil: Lizama, Carlos. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Nuñez, Elizabeth. Pontificia Universidad Católica de Chile; Chile
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Fil: Abramovich, Dalhia Nurit. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Orge, Felipe. Pontificia Universidad Católica de Chile; Chile
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Fil: Oliva, Bárbara. Pontificia Universidad Católica de Chile; Chile
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Fil: Orellana, Renán. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Villalon, Manuel. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Moreno, Ricardo D.. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Tesone, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Rokka, Anne. Universidad Andrés Bello; Chile
dc.description.fil
Fil: Corthals, Garry. Universidad Andrés Bello; Chile
dc.description.fil
Fil: Croxatto, Horacio B.. Universidad de Santiago de Chile; Chile
dc.description.fil
Fil: Parborell, Maria Fernanda Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Owen, Gareth I.. Pontificia Universidad Católica de Chile; Chile
dc.journal.title
Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1210/en.2012-1945
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article/154/5/1885/2423594
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