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dc.contributor.author
Faccia, Paula Andrea  
dc.contributor.author
Pardini, Francisco Martín  
dc.contributor.author
Amalvy, Javier  
dc.date.available
2024-04-30T11:06:50Z  
dc.date.issued
2015  
dc.identifier.citation
Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate; 3° Reunión Internacional de Ciencias Farmacéuticas; Córdoba; Argentina; 2014; 1-1  
dc.identifier.issn
2320-5148  
dc.identifier.uri
http://hdl.handle.net/11336/234240  
dc.description.abstract
Smart polymerslike pH-sensitive systems can improve the pharmacological treatment ofdiseases. Topical application is perhaps the most typical treatment practice inophthalmic therapies, however it is inefficient and sometimes produces sideeffects. A possibility to improve drug residence time and bioavailability isthe use of a pH-sensitive hydrogel as a vehicle to control the drug delivery.In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate(HEMA) with different proportions of 2-(diisopropylamino)ethyl methacrylate(DPA) and different amounts of cross-linker agent, ethylene glycoldimethacrylate (EGDMA) are evaluated as drugdelivery systems for ophthalmic therapies. Drug load and release studies atdifferent pH values were evaluated using dexamethasone-21 phosphate (DXP) as amodel drug. The interaction between the polymer matrix and the drug was studiedby IR spectroscopy (FTIR), and drug distribution and film morphology atdifferent pH values were studied by scanning electron microscopy (SEM). Theresults show that the loading of DXP increases with DPA content andcrosslinking degree. Also the incorporation of DXP into the matrix depends onthe medium pH and increase at basic pH. SEM images show important morphologicalchanges when varying the medium pH and it can be seen the presence of the DXPloading in the polymer matrix. FTIR spectra of copolymers show an interactionbetween the drug and the polymer matrix through the shifting of the carbonylstretching band. The release of DXP from copolymers of HEMA and DPA issensitive to small pH variations in the range of 7.00 and 7.80. Kineticsreleases shows case-II or anomalous diffusion behavior depending on theHEMA/DPA ratio. At medium ocular pH (7.40) the exponents values (n)obtained for the hydrogels containing 10 wt. % of DPA are close to 1.0,suggesting a case-II transport and for hydrogels containing 30 wt. % of DPA then values are between 0.5 and 1 indicating an anomalous behavior.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Society of Pharmaceutical Sciences and Research  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
HIDROGELES pH RESPONSIVOS  
dc.subject
LIBERACIÓNCONTROLADA  
dc.subject
DEXAMETASONA-21 FOSFATO  
dc.subject.classification
Otras Ciencias Químicas  
dc.subject.classification
Ciencias Químicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.type
info:eu-repo/semantics/conferenceObject  
dc.type
info:ar-repo/semantics/documento de conferencia  
dc.date.updated
2024-04-11T21:24:54Z  
dc.journal.pagination
1-1  
dc.journal.pais
India  
dc.journal.ciudad
Jhansi  
dc.description.fil
Fil: Faccia, Paula Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina  
dc.description.fil
Fil: Pardini, Francisco Martín. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina  
dc.description.fil
Fil: Amalvy, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://ijpsr.com/wp-content/uploads/2015/05/Proceedings-RICIFa2014-Cordoba-ARGENTINA.pdf  
dc.conicet.rol
Autor  
dc.conicet.rol
Autor  
dc.conicet.rol
Autor  
dc.coverage
Internacional  
dc.type.subtype
Reunión  
dc.description.nombreEvento
3° Reunión Internacional de Ciencias Farmacéuticas  
dc.date.evento
2014-09-18  
dc.description.ciudadEvento
Córdoba  
dc.description.paisEvento
Argentina  
dc.type.publicacion
Journal  
dc.description.institucionOrganizadora
Universidad Nacional de Córdoba. Facultad de Ciencias Químicas  
dc.source.revista
International Journal Of Pharmaceutical Sciences And Research  
dc.date.eventoHasta
2014-09-19  
dc.type
Reunión