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dc.contributor.author
Faccia, Paula Andrea
dc.contributor.author
Pardini, Francisco Martín
dc.contributor.author
Amalvy, Javier
dc.date.available
2024-04-30T11:06:50Z
dc.date.issued
2015
dc.identifier.citation
Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate; 3° Reunión Internacional de Ciencias Farmacéuticas; Córdoba; Argentina; 2014; 1-1
dc.identifier.issn
2320-5148
dc.identifier.uri
http://hdl.handle.net/11336/234240
dc.description.abstract
Smart polymerslike pH-sensitive systems can improve the pharmacological treatment ofdiseases. Topical application is perhaps the most typical treatment practice inophthalmic therapies, however it is inefficient and sometimes produces sideeffects. A possibility to improve drug residence time and bioavailability isthe use of a pH-sensitive hydrogel as a vehicle to control the drug delivery.In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate(HEMA) with different proportions of 2-(diisopropylamino)ethyl methacrylate(DPA) and different amounts of cross-linker agent, ethylene glycoldimethacrylate (EGDMA) are evaluated as drugdelivery systems for ophthalmic therapies. Drug load and release studies atdifferent pH values were evaluated using dexamethasone-21 phosphate (DXP) as amodel drug. The interaction between the polymer matrix and the drug was studiedby IR spectroscopy (FTIR), and drug distribution and film morphology atdifferent pH values were studied by scanning electron microscopy (SEM). Theresults show that the loading of DXP increases with DPA content andcrosslinking degree. Also the incorporation of DXP into the matrix depends onthe medium pH and increase at basic pH. SEM images show important morphologicalchanges when varying the medium pH and it can be seen the presence of the DXPloading in the polymer matrix. FTIR spectra of copolymers show an interactionbetween the drug and the polymer matrix through the shifting of the carbonylstretching band. The release of DXP from copolymers of HEMA and DPA issensitive to small pH variations in the range of 7.00 and 7.80. Kineticsreleases shows case-II or anomalous diffusion behavior depending on theHEMA/DPA ratio. At medium ocular pH (7.40) the exponents values (n)obtained for the hydrogels containing 10 wt. % of DPA are close to 1.0,suggesting a case-II transport and for hydrogels containing 30 wt. % of DPA then values are between 0.5 and 1 indicating an anomalous behavior.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society of Pharmaceutical Sciences and Research
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HIDROGELES pH RESPONSIVOS
dc.subject
LIBERACIÓNCONTROLADA
dc.subject
DEXAMETASONA-21 FOSFATO
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2024-04-11T21:24:54Z
dc.journal.pagination
1-1
dc.journal.pais
India
dc.journal.ciudad
Jhansi
dc.description.fil
Fil: Faccia, Paula Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
dc.description.fil
Fil: Pardini, Francisco Martín. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
dc.description.fil
Fil: Amalvy, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://ijpsr.com/wp-content/uploads/2015/05/Proceedings-RICIFa2014-Cordoba-ARGENTINA.pdf
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.coverage
Internacional
dc.type.subtype
Reunión
dc.description.nombreEvento
3° Reunión Internacional de Ciencias Farmacéuticas
dc.date.evento
2014-09-18
dc.description.ciudadEvento
Córdoba
dc.description.paisEvento
Argentina
dc.type.publicacion
Journal
dc.description.institucionOrganizadora
Universidad Nacional de Córdoba. Facultad de Ciencias Químicas
dc.source.revista
International Journal Of Pharmaceutical Sciences And Research
dc.date.eventoHasta
2014-09-19
dc.type
Reunión
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