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dc.contributor.author
Umpiérrez, Analía Alejandra Sofía
dc.contributor.author
Scavone, Paola
dc.contributor.author
Romanin, David Emmanuel
dc.contributor.author
Marqués, Juan Martín
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Chabalgoity Rodríguez, José Alejandro
dc.contributor.author
Rumbo, Martín
dc.contributor.author
Zunino, Pablo
dc.date.available
2017-08-31T18:58:04Z
dc.date.issued
2013-06
dc.identifier.citation
Umpiérrez, Analía Alejandra Sofía; Scavone, Paola; Romanin, David Emmanuel; Marqués, Juan Martín; Chabalgoity Rodríguez, José Alejandro; et al.; Innate immune responses to Proteus mirabilis flagellin in the urinary tract; Elsevier Masson; Microbes and Infection; 15; 10-11; 6-2013; 688-696
dc.identifier.issn
1286-4579
dc.identifier.uri
http://hdl.handle.net/11336/23369
dc.description.abstract
Flagella are bacterial virulence factors allowing microorganisms to move over surfaces. Flagellin, the structural component of flagella, is sensed by the host via Toll and NOD-like receptors and triggers pro-inflammatory responses. The use of Toll-like receptors agonists to modulate innate immune responses has aroused great interest as an alternative to improve the treatment of diverse infectious diseases. Proteus mirabilis is a Gram negative bacterium that causes urinary tract infections in humans. In the present work we used different approaches to study the ability of P. mirabilis flagellin to induce an innate immune response. We demonstrated that P. mirabilis flagellin has the ability to induce pro-inflammatory chemokines expression in T24 bladder cultures cells and in the mouse bladder after instillation. It was evidenced also that flagellin from different P. mirabilis strains differed in their capacity to induce an innate immune response in the CacoCCL20-Luc system. Also, flagellin elicited inflammation, with recruitment of leukocytes to the bladder epithelium. Flagellin instillation before an experimental P. mirabilis infection showed that the inflammatory response due to flagellin did not help to clear the infection but favored bacterial colonization. Thus, induction of inflammatory response in the bladder did not contribute to P. mirabilis infection neutralization
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Masson
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Proteus Mirabilis
dc.subject
Uti
dc.subject
Flagellin
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Innate Immune Response
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Innate immune responses to Proteus mirabilis flagellin in the urinary tract
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-28T14:29:18Z
dc.journal.volume
15
dc.journal.number
10-11
dc.journal.pagination
688-696
dc.journal.pais
Francia
dc.journal.ciudad
París
dc.description.fil
Fil: Umpiérrez, Analía Alejandra Sofía. Instituto de Investigaciones Biológicas "Clemente Estable"; Uruguay
dc.description.fil
Fil: Scavone, Paola. Instituto de Investigaciones Biológicas "Clemente Estable"; Uruguay
dc.description.fil
Fil: Romanin, David Emmanuel. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigaciones del Sistema Inmune; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Marqués, Juan Martín. Universidad de la República; Uruguay
dc.description.fil
Fil: Chabalgoity Rodríguez, José Alejandro. Universidad de la República; Uruguay
dc.description.fil
Fil: Rumbo, Martín. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigaciones del Sistema Inmune; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Zunino, Pablo. Instituto de Investigaciones Biológicas "Clemente Estable"; Uruguay
dc.journal.title
Microbes and Infection
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.micinf.2013.06.007
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1286457913001226
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