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dc.contributor.author
Leblanc, Jean Guy Joseph
dc.contributor.author
Aubry, Camille
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Cortes-Perez, Naima G.
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de Moreno, Maria Alejandra
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Vergnolle, Nathalie
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Langella, Philippe
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Azevedo, Vasco
dc.contributor.author
Chatel, Jean-Marc
dc.contributor.author
Miyoshi, Anderson
dc.contributor.author
Berúdez-Humarán, Luis G.
dc.date.available
2015-10-05T16:18:45Z
dc.date.issued
2013-07
dc.identifier.citation
Leblanc, Jean Guy Joseph; Aubry, Camille; Cortes-Perez, Naima G.; de Moreno, Maria Alejandra; Vergnolle, Nathalie; et al.; Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update; Oxford University Press; Fems Microbiology Letters; 344; 1; 7-2013; 1-9
dc.identifier.issn
0378-1097
dc.identifier.uri
http://hdl.handle.net/11336/2317
dc.description.abstract
Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms naturally present in many foods and those have proved to be effective mucosal delivery vectors. Moreover, some specific strains of LAB exert beneficial properties (known as probiotic effect) on both human and animal health. Although probiotic effects are strain-specific traits, it is theoretically possible, using genetic engineering techniques, to design strains that can exert a variety of beneficial properties. During the two past decades, a large variety of therapeutic molecules has been successfully expressed in LAB, and although this field has been largely reviewed in recent years, approximately 20 new publications appear each year. Thus, the aim of this minireview is not to extensively assess the entire literature but to update progress made within the last 2 years regarding the use of the model LAB Lactococcus lactis and certain species of lactobacilli as live recombinant vectors for the development of new safe mucosal vaccine.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lactic Acid Bactera
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Mucosal Vaccines
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Cytokines
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Therapeutic Molecules
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Lactococcus
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Lactobacillus
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Otras Ingenierías y Tecnologías
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Otras Ingenierías y Tecnologías
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
1574-6968
dc.journal.volume
344
dc.journal.number
1
dc.journal.pagination
1-9
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina. Universidad Nacional de Tucuman. Facultad de Medicina. Departamento de Investigacion. Catedra de Metodologia de la Invest.cientifica; Argentina
dc.description.fil
Fil: Aubry, Camille. Institut National de la Recherche Agronomique; Francia;
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Fil: Cortes-Perez, Naima G.. Institut National de la Recherche Agronomique; Francia;
dc.description.fil
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
dc.description.fil
Fil: Vergnolle, Nathalie. Centre National de la Recherche Scientifique; Francia; . Universite Paul Sabatier; Francia;
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Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia;
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Fil: Azevedo, Vasco. Universidade Federal Do Minas Gerais; Brasil;
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Fil: Chatel, Jean-Marc. Institut National de la Recherche Agronomique; Francia;
dc.description.fil
Fil: Miyoshi, Anderson. Universidade Federal Do Minas Gerais; Brasil;
dc.description.fil
Fil: Berúdez-Humarán, Luis G.. Institut National de la Recherche Agronomique; Francia;
dc.journal.title
Fems Microbiology Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://femsle.oxfordjournals.org/content/344/1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/1574-6968.12159
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