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dc.contributor.author
Scanarotti, Ignacio Gabriel
dc.contributor.author
Sain, Juliana
dc.contributor.author
Fabro, Ana Patricia
dc.contributor.author
Bernal, Claudio Adrian
dc.date.available
2024-04-03T11:54:47Z
dc.date.issued
2024-03
dc.identifier.citation
Scanarotti, Ignacio Gabriel; Sain, Juliana; Fabro, Ana Patricia; Bernal, Claudio Adrian; Virgin flaxseed oil supplemented or not with tocopherols and phytosterols prevents liver steatosis induced by high-fat diets in male Wistar rats; Wiley VCH Verlag; European Journal of Lipid Science and Technology; 3-2024; 1-12
dc.identifier.issn
1438-7697
dc.identifier.uri
http://hdl.handle.net/11336/231740
dc.description.abstract
This study aimed to investigate the effect of a virgin flaxseed oil (FO) rich in n-3 PUFA, supplemented or not with a bioactive supplement (BS) containing tocopherols and phytosterols on the prevention of NAFLD in a high-fat (HF) animal model. Male Wistar rats were fed 60 days with a recommended (SO7, soybean oil 7%), or a HF diet (fat, 30%) containing soybean (SO30), corn (CO30), or FO (FO30) or the same oils supplemented with 1% of BS (SO30BS, CO30BS or FO30BS, respectively). Hepatic and dietary FA composition, triacylglycerides (TAG) content in serum and liver, nutritional parameters, in vivo TAG-secretion rate, liver histology, mRNA levels of β-oxidation-related genes, and CPT-1a enzyme activity were determined. At HF levels, FO30 and FO30BS groups showed the highest total n-3 PUFA levels in diets and were associated with lower weight gain, liver TAG content and microsteatosis degree. The CPT-1a activity was enhanced in FO30 and FO30BS, showing differences only by the type of dietary oil. The BS supplementation induced an increase in the β-oxidation-related gene expression. Virgin FO prevented liver steatosis and hepatomegaly induced by HF diets. The BS supplementation reduced body fat accumulation and enhanced expression of β-oxidation related genes, without affecting hepatic TAG content.Practical applications: Scientific knowledge of functional lipids with high oxidative stability and biological activity has great practical application in reducing non-communicable chronic diseases.This study provides evidence on the potential synergic and complementary effects of virgin FO, TP, and PS to be used for the prevention of the metabolic hepatic disorders involved during the evolution of the different steps of NAFLD. Specifically, based on different biological mechanisms, this stable combination of bioactive lipids could prevent not only the development of exacerbated hepatic TAG accumulation but also the hepatocellular injury seen at different stages from hepatic steatosis to steatohepatitis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley VCH Verlag
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
FLAXSEED OIL
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TOCOPHEROLS
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PHYTOSTEROLS
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HIGH FAT DIETS
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STEATOSIS
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Nutrición, Dietética
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Virgin flaxseed oil supplemented or not with tocopherols and phytosterols prevents liver steatosis induced by high-fat diets in male Wistar rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-04-03T11:01:18Z
dc.identifier.eissn
1438-9312
dc.journal.pagination
1-12
dc.journal.pais
Alemania
dc.journal.ciudad
Weinheim
dc.description.fil
Fil: Scanarotti, Ignacio Gabriel. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.description.fil
Fil: Sain, Juliana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.description.fil
Fil: Fabro, Ana Patricia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
dc.description.fil
Fil: Bernal, Claudio Adrian. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.journal.title
European Journal of Lipid Science and Technology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/ejlt.202300203
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ejlt.202300203
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