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dc.contributor.author
Deco, Gustavo
dc.contributor.author
Sanz Perl Hernandez, Yonatan
dc.contributor.author
Ponce Alvarez, Adrián
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Tagliazucchi, Enzo Rodolfo
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Whybrow, Peter C.
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Fuster, Joaquín
dc.contributor.author
Kringelbach, Morten L.
dc.date.available
2024-02-27T12:40:10Z
dc.date.issued
2023-08
dc.identifier.citation
Deco, Gustavo; Sanz Perl Hernandez, Yonatan; Ponce Alvarez, Adrián; Tagliazucchi, Enzo Rodolfo; Whybrow, Peter C.; et al.; One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 227; 102468; 8-2023; 1-13
dc.identifier.issn
0301-0082
dc.identifier.uri
http://hdl.handle.net/11336/228575
dc.description.abstract
Surviving and thriving in a complex world require intricate balancing of higher order brain functions with essential survival-related behaviours. Exactly how this is achieved is not fully understood but a large body of work has shown that different regions in the prefrontal cortex (PFC) play key roles for diverse cognitive and emotional tasks including emotion, control, response inhibition, mental set shifting and working memory. We hypothesised that the key regions are hierarchically organised and we developed a framework for discovering the driving brain regions at the top of the hierarchy, responsible for steering the brain dynamics of higher brain function. We fitted a time-dependent whole-brain model to the neuroimaging data from large-scale Human Connectome Project with over 1000 participants and computed the entropy production for rest and seven tasks (covering the main domains of cognition). This thermodynamics framework allowed us to identify the main common, unifying drivers steering the orchestration of brain dynamics during difficult tasks; located in key regions of the PFC (inferior frontal gyrus, lateral orbitofrontal cortex, rostral and caudal frontal cortex and rostral anterior cingulate cortex). Selectively lesioning these regions in the whole-brain model demonstrated their causal mechanistic importance. Overall, this shows the existence of a ‘ring’ of specific PFC regions ruling over the orchestration of higher brain function.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
BRAIN DYNAMICS
dc.subject
COREPERIPHERY
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NEUROIMAGING
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THERMODYNAMICS
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WHOLE-BRAIN MODELLING
dc.subject.classification
Otras Ciencias Físicas
dc.subject.classification
Ciencias Físicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-26T11:05:02Z
dc.journal.volume
227
dc.journal.number
102468
dc.journal.pagination
1-13
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Deco, Gustavo. Universitat Pompeu Fabra; España. Institució Catalana de Recerca i Estudis Avancats; España
dc.description.fil
Fil: Sanz Perl Hernandez, Yonatan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universitat Pompeu Fabra; España. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
dc.description.fil
Fil: Ponce Alvarez, Adrián. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universidad Adolfo Ibañez; Chile
dc.description.fil
Fil: Whybrow, Peter C.. University of Oxford; Reino Unido. University of California; Estados Unidos
dc.description.fil
Fil: Fuster, Joaquín. University of California; Estados Unidos. University of Oxford; Reino Unido
dc.description.fil
Fil: Kringelbach, Morten L.. University of Oxford; Reino Unido. University Aarhus; Dinamarca
dc.journal.title
Progress In Neurobiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0301008223000692
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pneurobio.2023.102468
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