Mostrar el registro sencillo del ítem
dc.contributor.author
Mohammadi, Mohammad Ali
dc.contributor.author
Mansouri, Mehdi
dc.contributor.author
Derakhshani, Ali
dc.contributor.author
Rezaie, Masoud
dc.contributor.author
Borhani, Mehdi
dc.contributor.author
Nasibi, Saeid
dc.contributor.author
Mousavi, Seyed Mohammad
dc.contributor.author
Afgar, Ali
dc.contributor.author
Macchiaroli, Natalia
dc.contributor.author
Rosenzvit, Mara Cecilia
dc.contributor.author
Harandi, Majid Fasihi
dc.date.available
2024-02-22T11:43:44Z
dc.date.issued
2023-03
dc.identifier.citation
Mohammadi, Mohammad Ali; Mansouri, Mehdi; Derakhshani, Ali; Rezaie, Masoud; Borhani, Mehdi; et al.; MicroRNA-Transcription factor regulatory networks in the early strobilar development of Echinococcus granulosus protoscoleces; BioMed Central; BMC Genomics; 24; 1; 3-2023; 1-13
dc.identifier.issn
1471-2164
dc.identifier.uri
http://hdl.handle.net/11336/227986
dc.description.abstract
Background: Echinococcus granulosus sensu lato has a complex developmental biology with a variety of factors relating to both intermediate and final hosts. To achieve maximum parasite adaptability, the development of the cestode is dependent on essential changes in transcript regulation. Transcription factors (TFs) and miRNAs are known as master regulators that affect the expression of downstream genes through a wide range of metabolic and signaling pathways. In this study, we aimed to develop a regulatory miRNA-Transcription factor (miRNA-TF) network across early developmental stages of E. granulosus protoscoleces by performing in silico analysis, and to experimentally validate TFs expression in protoscoleces obtained from in vitro culture, and from in vivo experiments. Results: We obtained list of 394 unique E. granulosus TFs and matched them with 818 differentially expressed genes which identified 41 predicted TFs with differential expression. These TFs were used to predict the potential targets of 31 differentially expressed miRNAs. As a result, eight miRNAs and eight TFs were found, and the predicted network was constructed using Cytoscape. At least four miRNAs (egr-miR-124a, egr-miR-124b-3p, egr-miR-745-3p, and egr-miR-87-3p) and their corresponding differentially expressed TFs (Zinc finger protein 45, Early growth response protein 3, Ecdysone induced protein 78c and ETS transcription factor elf 2) were highlighted in this investigation. The expression of predicted differentially expressed TFs obtained from in vitro and in vivo experiments, were experimentally validated by quantitative polymerase chain reaction. This confirmed findings of RNA-seq data. Conclusion: miRNA-TF networks presented in this study control some of the most important metabolic and signaling pathways in the development and life cycle of E. granulosus, providing a potential approach for disrupting the early hours of dog infection and preventing the development of the helminth in the final host.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CANINE ECHINOCOCCOSIS
dc.subject
DOG INTESTINE
dc.subject
ECHINOCOCCUS GRANULOSUS SENSU STRICTO
dc.subject
GENE REGULATION
dc.subject
PEPSIN
dc.subject
TRANSCRIPTOME
dc.subject.classification
Parasitología
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
MicroRNA-Transcription factor regulatory networks in the early strobilar development of Echinococcus granulosus protoscoleces
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-20T12:51:27Z
dc.journal.volume
24
dc.journal.number
1
dc.journal.pagination
1-13
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Mohammadi, Mohammad Ali. Kerman University of Medical Sciences; Irán
dc.description.fil
Fil: Mansouri, Mehdi. Shahid Bahonar University of Kerman; Irán
dc.description.fil
Fil: Derakhshani, Ali. Kerman University of Medical Sciences; Irán
dc.description.fil
Fil: Rezaie, Masoud. Kerman University of Medical Sciences; Irán
dc.description.fil
Fil: Borhani, Mehdi. Jilin University; China
dc.description.fil
Fil: Nasibi, Saeid. Kerman University of Medical Sciences; Irán
dc.description.fil
Fil: Mousavi, Seyed Mohammad. Kerman University of Medical Sciences; Irán
dc.description.fil
Fil: Afgar, Ali. Kerman University of Medical Sciences; Irán
dc.description.fil
Fil: Macchiaroli, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Rosenzvit, Mara Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Harandi, Majid Fasihi. Kerman University of Medical Sciences; Irán
dc.journal.title
BMC Genomics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s12864-023-09199-3
Archivos asociados