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dc.contributor.author
Campos Carraro, Cristina
dc.contributor.author
Turck, Patrick
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De Lima Seolin, Bruna Gazzi
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Tavares, Angela Maria Vicente
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Dos Santos Lacerda, Denise
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Corssac, Giana Blume
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Teixeira, Rayane Brinck
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Hickmann, Alexandre
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Llesuy, Susana Francisca
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Da Rosa Araujo, Alex Sander
dc.contributor.author
Belló-Klein, Adriane
dc.date.available
2024-02-22T11:07:52Z
dc.date.issued
2018-11
dc.identifier.citation
Campos Carraro, Cristina; Turck, Patrick; De Lima Seolin, Bruna Gazzi; Tavares, Angela Maria Vicente; Dos Santos Lacerda, Denise; et al.; Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats; Lippincott Williams; Journal of Cardiovascular Pharmacology; 72; 5; 11-2018; 214-221
dc.identifier.issn
0160-2446
dc.identifier.uri
http://hdl.handle.net/11336/227942
dc.description.abstract
There is an increase in oxidative stress and apoptosis signaling during the transition from hypertrophy to right ventricular (RV) failure caused by pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT). In this study, it was evaluated the action of copaiba oil on the modulation of proteins involved in RV apoptosis signaling in rats with PAH. Male Wistar rats (±170 g, n = 7/group) were divided into 4 groups: control, MCT, copaiba oil, and MCT + copaiba oil. PAH was induced by MCT (60 mg/kg intraperitoneally) and, 7 days later, treatment with copaiba oil (400 mg/kg by gavage) was given for 14 days. Echocardiographic and hemodynamic measurements were performed, and the RV was collected for morphometric evaluations, oxidative stress, apoptosis, and cell survival signaling, and eNOS protein expression. Copaiba oil reduced RV hypertrophy (24%), improved RV systolic function, and reduced RV end-diastolic pressure, increased total sulfhydryl levels and eNOS protein expression, reduced lipid and protein oxidation, and the expression of proteins involved in apoptosis signaling in the RV of MCT + copaiba oil as compared to MCT group. In conclusion, copaiba oil reduced oxidative stress, and apoptosis signaling in RV of rats with PAH, which may be associated with an improvement in cardiac function caused by this compound.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
APOPTOSIS
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COPAIBA OIL
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MONOCROTALINE
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OXIDATIVE STRESS
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PULMONARY ARTERIAL HYPERTENSION
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-12-18T11:58:10Z
dc.journal.volume
72
dc.journal.number
5
dc.journal.pagination
214-221
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Campos Carraro, Cristina. Universidade Federal do Rio Grande do Sul; Brasil
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Fil: Turck, Patrick. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: De Lima Seolin, Bruna Gazzi. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Tavares, Angela Maria Vicente. Universidade Federal do Rio Grande do Sul; Brasil
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Fil: Dos Santos Lacerda, Denise. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Corssac, Giana Blume. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Teixeira, Rayane Brinck. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Hickmann, Alexandre. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
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Fil: Da Rosa Araujo, Alex Sander. Universidade Federal do Rio Grande do Sul; Brasil
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Fil: Belló-Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
dc.journal.title
Journal of Cardiovascular Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/cardiovascularpharm/abstract/2018/11000/copaiba_oil_attenuates_right_ventricular.2.aspx
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/FJC.0000000000000617
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