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dc.contributor.author
Radisic, Marcelo Victor
dc.contributor.author
Pujato, Natalia Rosana
dc.contributor.author
Bravo, Pablo Martin
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del Grosso, Roxana Constanza
dc.contributor.author
Hunter, Martin
dc.contributor.author
Beltramino, Santiago
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Linares González, Laura
dc.contributor.author
Cornet, María Lucía
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del Carmen Rial, Maria
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Franzini, Rosa Livia
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Dotta, Ana C.
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León, Luis Roberto
dc.contributor.author
Walther, Javier
dc.contributor.author
Uva, Pablo Daniel
dc.contributor.author
Werber, Gustavo
dc.date.available
2024-01-30T16:00:48Z
dc.date.issued
2022-12
dc.identifier.citation
Radisic, Marcelo Victor; Pujato, Natalia Rosana; Bravo, Pablo Martin; del Grosso, Roxana Constanza; Hunter, Martin; et al.; Tuberculosis treatment without rifampin in kidney/kidney–pancreas transplantation: A case series report; Wiley Blackwell Publishing, Inc; Transplant Infectious Disease; 24; 6; 12-2022; 1-11
dc.identifier.issn
1398-2273
dc.identifier.uri
http://hdl.handle.net/11336/225279
dc.description.abstract
Background: The best approach to tuberculosis (TB) treatment in transplanted patients is still unknown. Current guidelines are based on evidence either extrapolated from other populations or observational. Rifampin-containing regimens have strong pharmacokinetic interactions with immunosuppressive regimens, with high rates of organ dysfunction and ∼20% mortality. This report describes the results obtained using non-rifampin-containing regimens to treat confirmed TB in adult patients with kidney/kidney–pancreas transplantation. Methods: Retrospective data analysis from confirmed TB cases in adult kidney/kidney–pancreas transplant recipients (2006–2019), treated “de novo” with non-rifampin-containing regimens. Results: Fifty-seven patients had confirmed TB. Thirty patients were treated “de novo” with non-rifampin-containing regimens. These patients’ mean age was 49.24 (±11.50) years. Induction immunosuppression was used in 22 patients. Maintenance immunosuppression was tacrolimus–mycophenolate–steroids in 13 (43%), sirolimus–mycophenolate–steroids in 6 (20%), and other immunosuppressive regimens in 11 (36%). Belatacept was used in four patients. TB localizations: pulmonary 43%; disseminated 23%; extrapulmonary 33%. Twenty-seven (90%) patients completed treatment with isoniazid, ethambutol, and levofloxacin (12 months, 23; 9 months, 3; 6 months, 1); 12 of these patients also received pyrazinamide for the first 2 months and were cured with functioning grafts. One patient (3%) lost the graft while on treatment. Two patients (7%) died while on TB treatment. Median (range) follow-up after completion of TB treatment was 32 (8–150) months. No TB relapses were observed. Conclusions: Results with non-rifampin-containing TB treatments in this case series were better (in terms of mortality and graft dysfunction) than those previously described with rifampin-containing regimens in transplanted patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
QUINOLONES
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RIFAMPIN
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SOLID ORGAN TRANSPLANTATION
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TREATMENT
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TUBERCULOSIS
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Trasplantes
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Tuberculosis treatment without rifampin in kidney/kidney–pancreas transplantation: A case series report
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-01-29T12:07:32Z
dc.journal.volume
24
dc.journal.number
6
dc.journal.pagination
1-11
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Radisic, Marcelo Victor. Instituto de Trasplante y Alta Complejidad; Argentina
dc.description.fil
Fil: Pujato, Natalia Rosana. Instituto de Trasplante y Alta Complejidad; Argentina
dc.description.fil
Fil: Bravo, Pablo Martin. Instituto de Trasplante y Alta Complejidad; Argentina
dc.description.fil
Fil: del Grosso, Roxana Constanza. Instituto de Trasplante y Alta Complejidad; Argentina
dc.description.fil
Fil: Hunter, Martin. Instituto de Trasplante y Alta Complejidad; Argentina
dc.description.fil
Fil: Beltramino, Santiago. Instituto de Trasplante y Alta Complejidad; Argentina
dc.description.fil
Fil: Linares González, Laura. Instituto de Trasplante y Alta Complejidad; Argentina
dc.description.fil
Fil: Cornet, María Lucía. Instituto de Trasplante y Alta Complejidad; Argentina
dc.description.fil
Fil: del Carmen Rial, Maria. Instituto de Trasplante y Alta Complejidad; Argentina
dc.description.fil
Fil: Franzini, Rosa Livia. Instituto de Trasplante y Alta Complejidad; Argentina
dc.description.fil
Fil: Dotta, Ana C.. Instituto de Trasplante y Alta Complejidad; Argentina
dc.description.fil
Fil: León, Luis Roberto. Instituto de Trasplante y Alta Complejidad; Argentina
dc.description.fil
Fil: Walther, Javier. Instituto de Trasplante y Alta Complejidad; Argentina
dc.description.fil
Fil: Uva, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Werber, Gustavo. Instituto de Trasplante y Alta Complejidad; Argentina
dc.journal.title
Transplant Infectious Disease
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/tid.13949
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