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dc.contributor.author
Sanchez, Romel Sebastian
dc.contributor.author
Sanchez, Sara Serafina del V.
dc.date.available
2017-08-07T20:46:31Z
dc.date.issued
2013-03
dc.identifier.citation
Sanchez, Romel Sebastian; Sanchez, Sara Serafina del V.; Characterization of pax1, pax9, and uncx sclerotomal genes during Xenopus laevis embryogenesis; Wiley; Developmental Dynamics; 242; 5; 3-2013; 572-579
dc.identifier.issn
1058-8388
dc.identifier.uri
http://hdl.handle.net/11336/21992
dc.description.abstract
Background: The axial skeleton develops from the sclerotome, a mesenchymal cell population derived from somites. Sclerotomal cells migrate from somites to the perinotochordal and perineural space where they differentiate into chondrocytes to form cartilage and bone. In anurans, little is known about the way how the sclerotome changes as development proceeds and how these events are regulated at the molecular level. Pax1, Pax9, and Uncx4.1 genes play a central role in the morphogenesis of the axial skeleton in vertebrates, regulating cell proliferation and chondrogenic specification of the sclerotome. Results: In this work, we cloned and examined through whole-mount in situ hybridization and reverse transcriptasepolymerase chain reaction the expression patterns of pax1, pax9, and uncx transcription factors in the anuran Xenopus laevis. Conclusions: We found that these genes are similarly expressed in the sclerotome and in the pharyngeal pouch. A detailed analysis of the location of these transcripts showed that they are expressed in different subdomains of the sclerotomal compartment and differ from that observed in other vertebrates.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Pax1
dc.subject
Pax9
dc.subject
Uncx
dc.subject
Sclerotome
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Characterization of pax1, pax9, and uncx sclerotomal genes during Xenopus laevis embryogenesis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-07T17:38:13Z
dc.journal.volume
242
dc.journal.number
5
dc.journal.pagination
572-579
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Sanchez, Romel Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; Argentina
dc.description.fil
Fil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; Argentina
dc.journal.title
Developmental Dynamics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/dvdy.23945
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/dvdy.23945/abstract
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