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dc.contributor.author
Crocker, Justin
dc.contributor.author
Abe, Namiko
dc.contributor.author
Rinaldi, Lucrezia
dc.contributor.author
McGregor, Alistair P.
dc.contributor.author
Frankel, Nicolás
dc.contributor.author
Wang, Shu
dc.contributor.author
Alsawadi, Ahmad
dc.contributor.author
Valenti, Philippe
dc.contributor.author
Plaza, Serge
dc.contributor.author
Payre, Francois
dc.contributor.author
Mann, Richard S.
dc.contributor.author
Stern, David L.
dc.date.available
2017-08-03T19:31:02Z
dc.date.issued
2014-12
dc.identifier.citation
Crocker, Justin; Abe, Namiko; Rinaldi, Lucrezia; McGregor, Alistair P.; Frankel, Nicolás; et al.; Low Affinity Binding Site Clusters Confer Hox Specificity and Regulatory Robustness; Cell Press; Cell; 160; 1-2; 12-2014; 191-203
dc.identifier.issn
0092-8674
dc.identifier.uri
http://hdl.handle.net/11336/21831
dc.description.abstract
In animals, Hox transcription factors define regional identity in distinct anatomical domains. How Hox genes encode this specificity is a paradox, because different Hox proteins bind with high affinity in vitro to similar DNA sequences. Here, we demonstrate that the Hox protein Ultrabithorax (Ubx) in complex with its cofactor Extradenticle (Exd) bound specifically to clusters of very low affinity sites in enhancers of the shavenbaby gene of Drosophila. These low affinity sites conferred specificity for Ubx binding in vivo, but multiple clustered sites were required for robust expression when embryos developed in variable environments. Although most individual Ubx binding sites are not evolutionarily conserved, the overall enhancer architecture—clusters of low affinity binding sites—is maintained and required for enhancer function. Natural selection therefore works at the level of the enhancer, requiring a particular density of low affinity Ubx sites to confer both specific and robust expression.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Low Affinity Binding Site Clusters Confer Hox Specificity and Regulatory Robustness
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-05T15:02:39Z
dc.journal.volume
160
dc.journal.number
1-2
dc.journal.pagination
191-203
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Crocker, Justin. Howard Hughes Medical Institute; Estados Unidos
dc.description.fil
Fil: Abe, Namiko. Columbia University; Estados Unidos
dc.description.fil
Fil: Rinaldi, Lucrezia. Columbia University; Estados Unidos
dc.description.fil
Fil: McGregor, Alistair P.. Oxford Brookes University; Reino Unido
dc.description.fil
Fil: Frankel, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
dc.description.fil
Fil: Wang, Shu. New Jersey Neuroscience Institute; Estados Unidos
dc.description.fil
Fil: Alsawadi, Ahmad. Université de Toulouse; Francia. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Valenti, Philippe. Université de Toulouse; Francia. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Plaza, Serge. Université de Toulouse; Francia. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Payre, Francois. Université de Toulouse; Francia. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Mann, Richard S.. Columbia University; Estados Unidos
dc.description.fil
Fil: Stern, David L.. Howard Hughes Medical Institute; Estados Unidos
dc.journal.title
Cell
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cell.2014.11.041
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0092867414015189
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