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dc.contributor.author
Mainetti, Leandro Ernesto
dc.contributor.author
Rico, Maria Jose
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Fernández Zenobi, M. V.
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Perroud, Herman Andrés
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Roggero, Eduardo Angel
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Rozados, Viviana Rosa
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Scharovsky, Olga Graciela
dc.date.available
2017-07-31T22:09:24Z
dc.date.issued
2013-05
dc.identifier.citation
Mainetti, Leandro Ernesto; Rico, Maria Jose; Fernández Zenobi, M. V.; Perroud, Herman Andrés; Roggero, Eduardo Angel; et al.; Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas; Oxford University Press; Annals Of Oncology; 24; 9; 5-2013; 2310-2316
dc.identifier.issn
0923-7534
dc.identifier.uri
http://hdl.handle.net/11336/21683
dc.description.abstract
Background: Metronomic chemotherapy (MCT) refers to the chronic and equally spaced administration of low doses of different chemotherapy drugs, without extended rest periods. Herein, we investigated the therapeutic efficacy of metronomic cyclophosphamide (Cy) combined with doxorubicin (Dox) in two mouse mammary adenocarcinoma models. Materials and methods: Mice were s.c. challenged with M-234p or M-406 mammary tumors, and when the tumors reached ∼150 mm3 , they were treated with: (I) no treatment (controls); (II) Cy in the drinking water (30 mg/kg body weight/day); (III) Dox (0.5 mg/kg body weight i.p. three times/week); (IV) treated as (II) + (III). Mice challenged i.v. with M-234p or M-406 tumor cells received, on day 3, the same treatments. Results: We found that MCT with Cy plus Dox inhibited tumor growth, decreased lung metastases, and increased the median survival time, while having low toxic effect. Combined MCT was more effective than each monotherapy causing decrease in VEGF serum concentration and tumor proliferation rate plus increase in tumor apoptosis. Conclusion(s): The therapeutic benefits of combined MCT with Cy and Dox on mammary adenocarcinomas together with its low toxic effect profile suggest the possibility of future translation into the clinic.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Angiogenesis
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Cyclophosphamide
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Doxorubicin
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Mammary Adenocarcinomas
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Metronomic Chemotherapy
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Toxic Effect
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Oncología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-28T18:02:50Z
dc.journal.volume
24
dc.journal.number
9
dc.journal.pagination
2310-2316
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Mainetti, Leandro Ernesto. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Rico, Maria Jose. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Fernández Zenobi, M. V.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Perroud, Herman Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Roggero, Eduardo Angel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
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Fil: Rozados, Viviana Rosa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Scharovsky, Olga Graciela. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Annals Of Oncology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/annonc/mdt164
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdt164
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