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dc.contributor.author
Bivi, Nicoletta
dc.contributor.author
Pacheco Costa, Rafael
dc.contributor.author
Brun, Lucas Ricardo Martín
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Murphy, Thomas R.
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Farlow, Nathan R.
dc.contributor.author
Robling, Alexander G.
dc.contributor.author
Bellido, Teresita
dc.contributor.author
Plotkin, Lilian I.
dc.date.available
2017-07-31T22:09:16Z
dc.date.issued
2013-03
dc.identifier.citation
Bivi, Nicoletta; Pacheco Costa, Rafael; Brun, Lucas Ricardo Martín; Murphy, Thomas R.; Farlow, Nathan R.; et al.; Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice; Wiley; Journal Of Orthopaedic Research; 31; 7; 3-2013; 1075-1081
dc.identifier.issn
0736-0266
dc.identifier.uri
http://hdl.handle.net/11336/21682
dc.description.abstract
The osteocyte network is crucial for the response of bone to mechanical force. Within this network, connexin43 (Cx43) is thought to mediate the communication of osteocytes and osteoblasts among themselves and the exchange of small molecules with the extracellular milieu. Despite recent advances in understanding Cx43 role for the response of bone cells to mechanical stimulation, the contribution of Cx43 specifically in osteocytes to mechanotransduction in vivo is not well-known. We examined the anabolic response to ulnar axial loading of mice lacking Cx43 in osteocytes (Cx43DOt). Loading induced a greater increase in periosteal bone formation rate in Cx43DOt mice compared to control littermates, resulting from higher mineralizing surface and enhanced mineral apposition rate. Expression of b-catenin protein, a molecule implicated in mechanotransduction, was higher in bones from Cx43DOt mice, compared to littermate controls. In addition, MLO-Y4 osteocytic cells knocked-down for Cx43 exhibited higher b-catenin protein expression and enhanced response to mechanical stimulation. These findings suggest that osteocytes lacking Cx43 are “primed” to respond to mechanical stimulation and that absence of Cx43 in osteocytes unleashes bone formation, by a mechanism that might involve accumulation of b-catenin.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Connexin 43
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Bone Formation
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Osteocyte
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Mechanical Loading
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Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-28T18:03:09Z
dc.journal.volume
31
dc.journal.number
7
dc.journal.pagination
1075-1081
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Bivi, Nicoletta. Indiana University; Estados Unidos
dc.description.fil
Fil: Pacheco Costa, Rafael. Indiana University; Estados Unidos. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Brun, Lucas Ricardo Martín. Indiana University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Murphy, Thomas R.. Indiana University; Estados Unidos
dc.description.fil
Fil: Farlow, Nathan R.. Indiana University; Estados Unidos
dc.description.fil
Fil: Robling, Alexander G.. Indiana University; Estados Unidos
dc.description.fil
Fil: Bellido, Teresita. Indiana University; Estados Unidos
dc.description.fil
Fil: Plotkin, Lilian I.. Indiana University; Estados Unidos
dc.journal.title
Journal Of Orthopaedic Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jor.22341
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/jor.22341/abstract
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