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dc.contributor.author
Silveyra, María Ximena
dc.contributor.author
Andreu, Adriana Balbina
dc.date.available
2023-10-31T15:23:38Z
dc.date.issued
2023-06
dc.identifier.citation
Silveyra, María Ximena; Andreu, Adriana Balbina; Red-purple Andean potato polyphenols have an in vitro anti-neuroblastoma effect via mitochondrial dysfunction-induced apoptosis; Elsevier; Food Bioscience; 53; 6-2023; 1-9
dc.identifier.issn
2212-4292
dc.identifier.uri
http://hdl.handle.net/11336/216674
dc.description.abstract
Andean potatoes (Solanum tuberosum ssp. andigena) are a good source of dietary polyphenols, such as phenolic acid and flavonoids. These polyphenols have several beneficial effects on human health due to their antioxidant properties. Previously, we demonstrated that polyphenol extracts from Andean potato tubers exerted a concentration-dependent cytotoxic effect in human neuroblastoma cells. However, the mechanisms involved in this cytotoxic activity were not explored. Here, we show that polyphenols from Santa María tuber activated programmed cell death by caspase-independent apoptosis. They induced cell morphology changes, including the nucleus, and slightly affected the cell cycle. Furthermore, tuber polyphenols altered redox homeostasis and mitochondrial function of neuroblastoma cells, which increased the number of apoptotic cells. We also showed that neither Bcl-2 nor caspase-3 was involved in this mechanism of death. In summary, our results demonstrated that polyphenols from Santa María tuber are bioactive compounds that have mitochondria as a target and contribute to revalorizing Andean potatoes as a functional food. These findings suggest that they would be a good source of anti-tumor compounds that could induce tumor cell death even in apoptotic-resistant tumors, opening new therapeutic avenues.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANDEAN POTATO
dc.subject
ANTI-NEUROBLASTOMA ACTIVITY
dc.subject
BIOACTIVE COMPOUNDS
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FUNCTIONAL FOOD
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MITOCHONDRIA
dc.subject
POLYPHENOLS
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Red-purple Andean potato polyphenols have an in vitro anti-neuroblastoma effect via mitochondrial dysfunction-induced apoptosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-10-31T14:25:38Z
dc.identifier.eissn
2212-4306
dc.journal.volume
53
dc.journal.pagination
1-9
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Silveyra, María Ximena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Andreu, Adriana Balbina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina
dc.journal.title
Food Bioscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2212429223003747
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.fbio.2023.102723
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