Mostrar el registro sencillo del ítem
dc.contributor.author
Alarcón, Liliana P.
dc.contributor.author
Andrada, Heber Eduardo
dc.contributor.author
Olivera, Maria Eugenia
dc.contributor.author
Silva, Oscar Fernando
dc.contributor.author
Falcone, Ruben Dario
dc.date.available
2023-10-26T12:00:20Z
dc.date.issued
2022-05
dc.identifier.citation
Alarcón, Liliana P.; Andrada, Heber Eduardo; Olivera, Maria Eugenia; Silva, Oscar Fernando; Falcone, Ruben Dario; Carrier in carrier: catanionic vesicles based on amphiphilic cyclodextrins complexed with DNA as nanocarriers of doxorubicin; Elsevier Science; Journal of Molecular Liquids; 360; 5-2022; 1-11
dc.identifier.issn
0167-7322
dc.identifier.uri
http://hdl.handle.net/11336/216010
dc.description.abstract
Doxorubicin (Dox) is a very effective chemotherapeutic agent; however, it can induce various side effects on normal tissues because of their non-specific distribution in the body. Therefore, there is an urgent demand to develop systems to successfully carry drugs to the desired sites of therapeutic action while reducing side effects. The aim of this study was to evaluate the interaction between catanionic vesicles based on amphiphilic cyclodextrins (ModCBHD) and DNA–Dox complex as a supramolecular anticancer drugs carrier (ModCBHD-DNA-Dox). The complexes were characterized by dynamic light scattering (DLS), zeta potential (ζ), circular dichroism (CD), emission spectroscopy, atomic force microscope (AFM), transmission electron microscopy (TEM). The results showed that ModCBHD vesicles exhibit a positive surface charge that allows negatively charged DNA-Dox to wrap them. Besides, Dox interacts with DNA through intercalation of the tetracene ring system and by ionic interaction through the amino sugar residue of the drug. In addition, ModCBHD-DNA-Dox exhibit a small particle size and optimal monodisperse size distribution that can take advantage of the enhanced permeability and retention (EPR) effect in cancer therapy. In vitro release of Dox from ModCBHD-DNA-Dox was slower than from DNA–Dox, due to the increasing appearance of external complexes formed from partially intercalated Dox after all the available sites become occupied upon addition of ModCBHD. The study overall highlighted a novel strategy that combine vesicles prepared from amphiphilic cyclodextrins and DNA that can be used as alternative carriers for chemotherapeutic agents such as Dox with slow-release properties.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AMPHIPHILIC CYCLODEXTRINS
dc.subject
CATANIONIC VESICLES
dc.subject
DNA
dc.subject
DOXORUBICIN
dc.subject
DRUG NANOCARRIERS
dc.subject.classification
Química Coloidal
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Carrier in carrier: catanionic vesicles based on amphiphilic cyclodextrins complexed with DNA as nanocarriers of doxorubicin
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-10-25T12:52:58Z
dc.journal.volume
360
dc.journal.pagination
1-11
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Alarcón, Liliana P.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Andrada, Heber Eduardo. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
dc.description.fil
Fil: Olivera, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Silva, Oscar Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.description.fil
Fil: Falcone, Ruben Dario. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
dc.journal.title
Journal of Molecular Liquids
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0167732222010261?via%3Dihub
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.molliq.2022.119488
Archivos asociados