Artículo
The importance of RHAMM in the normal brain and gliomas: physiological and pathological roles
Pibuel, Matías Arturo
; Poodts, Daniela; Molinari, Yamila Azul
; Díaz, Mariángeles
; Amoia, Sofía; Byrne, Agustin Jesus; Hajos, Silvia Elvira
; Lompardía, Silvina Laura
; Franco, Paula Gabriela
Fecha de publicación:
10/2022
Editorial:
Nature Publishing Group
Revista:
British Journal Of Cancer
ISSN:
0007-0920
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Although the literature about the functions of hyaluronan and the CD44 receptor in the brain and brain tumours is extensive, the role of the receptor for hyaluronan-mediated motility (RHAMM) in neural stem cells and gliomas remain poorly explored. RHAMM is considered a multifunctional receptor which performs various biological functions in several normal tissues and plays a significant role in cancer development and progression. RHAMM was first identified for its ability to bind to hyaluronate, the extracellular matrix component associated with cell motility control. Nevertheless, additional functions of this protein imply the interaction with different partners or cell structures to regulate other biological processes, such as mitotic-spindle assembly, gene expression regulation, cell-cycle control and proliferation. In this review, we summarise the role of RHAMM in normal brain development and the adult brain, focusing on the neural stem and progenitor cells, and discuss the current knowledge on RHAMM involvement in glioblastoma progression, the most aggressive glioma of the central nervous system. Understanding the implications of RHAMM in the brain could be useful to design new therapeutic approaches to improve the prognosis and quality of life of glioblastoma patients.
Palabras clave:
RHAMM
,
GLIOMA
,
NEURAL STEM CELL
Archivos asociados
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Colecciones
Articulos(IDEHU)
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI
Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Pibuel, Matías Arturo; Poodts, Daniela; Molinari, Yamila Azul; Díaz, Mariángeles; Amoia, Sofía; et al.; The importance of RHAMM in the normal brain and gliomas: physiological and pathological roles; Nature Publishing Group; British Journal Of Cancer; 128; 1; 10-2022; 12-20
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