Artículo
Performance of Elecsys Anti-SARS CoV-2 (Roche) and VIDAS Anti-SARS CoV-2 (Biomérieux) for SARS-CoV-2 nucleocapsid and spike protein antibody detection
Riberi, Maria Ines
; Hernández Toledo, Marina Gabriela; Cid, Mariana Paula
; Tenaglia, María Magdalena; Alfaro, Jimena; Konigheim, Brenda Salome
; Aguilar, Juan Javier; Blanco, Sebastian; Spinsanti, Lorena Ivana; Diaz, Luis Adrian
; Rivarola, María Elisa
; Beranek, Mauricio Daniel
; Botiglieri, María Teresita; Gallego, Sandra Veronica
; Isa, María Beatriz
Fecha de publicación:
08/2022
Editorial:
International Federation of Clinical Chemistry and Laboratory Medicine
Revista:
Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine
ISSN:
1650-3414
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
IntroductionSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the novel viral pathogen that causes coronavirus disease 2019 (COVID-19) in humans, has spread worldwide since its identification in late 2019. The pandemic produced an accelerated development of new serological techniques for diagnosis.MethodsWe evaluated two commercial assays for serological diagnosis of SARS-CoV-2 infection, approved by the Administración Nacional de Medicamentos, Alimenos y Tecnología Médica (ANMAT) in Argentina: Elecsys Anti-SARS-CoV-2; Roche for nucleocapsid total antibody detection, and VIDAS Anti-SARSCoV-2 bioMérieux for spike protein IgG antibody detection. Sensitivity was assessed using a panel of 92 plasma samples from recovered COVID-19 patients who were positive for RT-PCR and positive for neutralizing antibodies by plaque reduction neutralization test (PRNT) and/or positive for IgG antibodies by indirect immunofluorescence assay (IFA). Specificity was determined studying 71 plasma samples collected during year 2018 prior to the COVID-19 pandemic. Assays were evaluated as stand-alone tests.ResultsSensitivity was 97.8% and 98.9% for the Roche and bioMérieux assays, respectively, specificity:98.5% (Roche) and 97.1% (bioMérieux), positive predictive value (PPV): 98.9% (Roche) and 97.8%(bioMérieux), and negative predictive value: (NPV) 97.2% (Roche) and 98.5% (bioMérieux).Additionally, Cohen?s kappa coefficient demonstrated high concordance (k=0.950) betweenRoche and bioMérieux.DiscussionIn conclusion, our results evidenced a very good performance for the nucleocapsid antibody assay (Roche) and the spike protein antibody assay (bioMérieux), thus both platforms are equallyadequate for indirect diagnosis of SARS-CoV-2 infection through total antibodies and IgG antibody detection, respectively.
Palabras clave:
SARS-CoV-2
,
COVID-19
,
NEUTRALIZING ANTIBODIES
,
DIAGNOSIS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos(IIBYT)
Articulos de INSTITUTO DE INVESTIGACIONES BIOLOGICAS Y TECNOLOGICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOLOGICAS Y TECNOLOGICAS
Citación
Riberi, Maria Ines; Hernández Toledo, Marina Gabriela; Cid, Mariana Paula; Tenaglia, María Magdalena; Alfaro, Jimena; et al.; Performance of Elecsys Anti-SARS CoV-2 (Roche) and VIDAS Anti-SARS CoV-2 (Biomérieux) for SARS-CoV-2 nucleocapsid and spike protein antibody detection; International Federation of Clinical Chemistry and Laboratory Medicine; Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine; 33; 2; 8-2022; 159-165
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