Artículo
The potential implication of decreased DHEA levels in the pathophysiology of chronic Chagas cardiomyopathy
Fecha de publicación:
03/2022
Editorial:
Elsevier Ireland
Revista:
International Journal of Cardiology
ISSN:
0167-5273
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The use of decision-analytic methods in medicine is appealing since they are helpful when trying to get a more insightful assessment of the patient status aimed at better clinical management. Within this setting, the current issue of IJC publishes a study in which its authors analyzed the levels of dehydroepiandrosterone sulfate (DHEA-S) in patients with chronic Chagas cardiomyopathy -CCC- to ascertain whether values of this adrenal steroid were related to cardiac compromise, in terms of clinical, biochemical, and cardiological endpoints [1]. Beyond their proper effects, compounds released during an inflammatory process signal the brain to activate the stress system, particularly the hypothalamic-pituitary-adrenal axis [2] leading to the production of adrenal steroids glucocorticoids (GCs), and DHEA which mainly circulates in the blood as a conjugated ester in the form of DHEAS. Such immune-endocrine interaction serves to orchestrate a more effective defense strategy against the insult [3].
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Articulos(IDICER)
Articulos de INSTITUTO DE INMUNOLOGIA CLINICA Y EXPERIMENTAL DE ROSARIO
Articulos de INSTITUTO DE INMUNOLOGIA CLINICA Y EXPERIMENTAL DE ROSARIO
Citación
Bottasso, Oscar Adelmo; The potential implication of decreased DHEA levels in the pathophysiology of chronic Chagas cardiomyopathy; Elsevier Ireland; International Journal of Cardiology; 350; 3-2022; 92-93
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