Mostrar el registro sencillo del ítem
dc.contributor.author
Garaicoa, Fuad Huaman
dc.contributor.author
Roisman, Alejandro
dc.contributor.author
Arias, Mariana
dc.contributor.author
Trila, Carla
dc.contributor.author
Fridmanis, Miguel
dc.contributor.author
Abeldaño, Alejandra
dc.contributor.author
Vanzulli, Silvia
dc.contributor.author
Narbaitz, Marina
dc.contributor.author
Slavutsky, Irma Rosa
dc.date.available
2023-09-05T14:51:43Z
dc.date.issued
2016-10
dc.identifier.citation
Garaicoa, Fuad Huaman; Roisman, Alejandro; Arias, Mariana; Trila, Carla; Fridmanis, Miguel; et al.; Genomic imbalances and microRNA transcriptional profiles in patients with mycosis fungoides; Springer; Tumor Biology; 37; 10; 10-2016; 13637-13647
dc.identifier.issn
1010-4283
dc.identifier.uri
http://hdl.handle.net/11336/210567
dc.description.abstract
Mycosis fungoides is the most common type of primary cutaneous T cell lymphoma. We have evaluated CDKN2A losses and MYC gains/amplifications by FISH analysis, as well as expression of miR-155 and members of the oncogenic cluster miR-17-92 (miR17, miR18a, miR19b, and miR92a) in MF patients with advanced disease. Formalin-fixed paraffin-embedded skin biopsies from 36 patients at diagnosis, 16 with tumoral MF (T-MF), 13 in histological transformation to a large T cell lymphoma (TR-MF), and 7 cases with folliculotropic variant (F-MF), were studied. Twenty cases showed genomic alterations (GAs): 8 (40 %) had CDKN2A deletion, 7 (35 %) showed MYC gain, and 5 (25 %) exhibited both alterations. GAs were more frequently observed in F-MF (p = 0.004) and TR-MF (p = 0.0001) than T-MF. GAs were significantly higher in cases presenting lesions in head, neck, and lower extremities compared to those observed in trunk and upper extremities (p = 0.03), when ≥25 % neoplastic cells were CD30 positive (p = 0.016) as well as in cases with higher Ki-67 proliferation index (p = 0.003). Patients with GAs showed bad response to treatment (p = 0.02) and short survival (p = 0.04). Furthermore, MF patients showed higher miRNA expression compared to controls (p ≤ 0.0223). T-MF showed higher miR17 and miR-18a expression compared to F-MF and TR-MF (p ≤ 0.0387) while miR19b, miR92a, and miR-155 showed increased levels in F-MF and TR-MF with respect to T-MF (p ≤ 0.0360). Increased expression of miR17 and miR19b in GA group compared to cases without alterations (p ≥ 0.0307) was also detected. Our results add new information about genomic imbalances in MF patients, particularly in F-MF, and extend the present view of miRNA deregulation in this disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
FISH
dc.subject
GENOMIC ALTERATIONS
dc.subject
MICRORNA EXPRESSION
dc.subject
MIR-155
dc.subject
MIR-17-92 CLUSTER
dc.subject
MYCOSIS FUNGOIDES
dc.subject.classification
Genética Humana
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Genomic imbalances and microRNA transcriptional profiles in patients with mycosis fungoides
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-09-05T12:08:03Z
dc.journal.volume
37
dc.journal.number
10
dc.journal.pagination
13637-13647
dc.journal.pais
Alemania
dc.journal.ciudad
Berlín
dc.description.fil
Fil: Garaicoa, Fuad Huaman. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Fundación Para Combatir la Leucemia; Argentina
dc.description.fil
Fil: Roisman, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Arias, Mariana. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; Argentina
dc.description.fil
Fil: Trila, Carla. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; Argentina
dc.description.fil
Fil: Fridmanis, Miguel. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Abeldaño, Alejandra. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; Argentina
dc.description.fil
Fil: Vanzulli, Silvia. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Narbaitz, Marina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Fundación Para Combatir la Leucemia; Argentina
dc.description.fil
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
Tumor Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s13277-016-5259-8
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s13277-016-5259-8
Archivos asociados