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dc.contributor.author
Soñora, Martín
dc.contributor.author
Barrera Guisasola, Exequiel Ernesto
dc.contributor.author
Pantano, Sergio
dc.date.available
2023-07-26T17:52:44Z
dc.date.issued
2022-02
dc.identifier.citation
Soñora, Martín; Barrera Guisasola, Exequiel Ernesto; Pantano, Sergio; The stressed life of a lipid in the Zika virus membrane; Elsevier Science; Biochimica et Biophysica Acta - Biomembranes; 1864; 1; 2-2022; 1-11
dc.identifier.issn
0005-2736
dc.identifier.uri
http://hdl.handle.net/11336/205669
dc.description.abstract
Protein-lipid interactions modulate a plethora of physiopathologic processes and have been the subject of countless studies. However, these kinds of interactions in the context of viral envelopes have remained relatively unexplored, partially because the intrinsically small dimensions of the molecular systems escape to the current resolution of experimental techniques. However, coarse-grained and multiscale simulations may fill that niche, providing nearly atomistic resolution at an affordable computational price. Here we use multiscale simulations to characterize the lipid-protein interactions in the envelope of the Zika Virus, a prominent member of the Flavivirus genus. Comparisons between the viral envelope and simpler molecular systems indicate that the viral membrane is under extreme pressures and asymmetric forces. Furthermore, the dense net of protein-protein contacts established by the envelope proteins creates poorly solvated regions that destabilize the external leaflet leading to a decoupled dynamics between both membrane layers. These findings lead to the idea that the Flaviviral membrane may store a significant amount of elastic energy, playing an active role in the membrane fusion process.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COARSE-GRAIN
dc.subject
FLAVIVIRUS
dc.subject
MOLECULAR DYNAMICS
dc.subject
SIMULATION
dc.subject
SIRAH
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VLP
dc.subject
ZIKA VIRUS
dc.subject.classification
Virología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
The stressed life of a lipid in the Zika virus membrane
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-18T14:26:16Z
dc.journal.volume
1864
dc.journal.number
1
dc.journal.pagination
1-11
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Soñora, Martín. Instituto Pasteur de Montevideo; Uruguay
dc.description.fil
Fil: Barrera Guisasola, Exequiel Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Pantano, Sergio. Instituto Pasteur de Montevideo; Uruguay
dc.journal.title
Biochimica et Biophysica Acta - Biomembranes
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0005273621002522
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbamem.2021.183804
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