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dc.contributor.author
Kezunovic, Nebojsa
dc.contributor.author
Hyde, James
dc.contributor.author
Simon, Christen
dc.contributor.author
Urbano Suarez, Francisco Jose
dc.contributor.author
Williams, D. Keith
dc.contributor.author
Garcia Rill, Edgar
dc.date.available
2017-07-13T18:31:38Z
dc.date.issued
2012-02
dc.identifier.citation
Kezunovic, Nebojsa; Hyde, James; Simon, Christen; Urbano Suarez, Francisco Jose; Williams, D. Keith; et al.; Gamma band activity in the developing parafascicular nucleus; American Physiological Society; Journal of Neurophysiology; 107; 3; 2-2012; 772-784
dc.identifier.issn
0022-3077
dc.identifier.uri
http://hdl.handle.net/11336/20369
dc.description.abstract
The parafascicular nucleus (Pf) receives cholinergic input from the pedunculopontine nucleus, part of the reticular activating system involved in waking and rapid eye movement (REM) sleep, and sends projections to the cortex. We tested the hypothesis that Pf neurons fire maximally at gamma band frequency (30–90 Hz), that this mechanism involves high-threshold voltage-dependent P/Q- and N-type calcium channels, and that this activity is enhanced by the cholinergic agonist carbachol (CAR). Patch-clamped 9- to 25-day-old rat Pf neurons (n = 299) manifested a firing frequency plateau at gamma band when maximally activated (31.5 ± 1.5 Hz) and showed gamma oscillations when voltage-clamped at holding potentials above −20 mV, and the frequency of the oscillations increased significantly with age (24.6 ± 3.8 vs. 51.6 ± 4.4 Hz, P < 0.001) but plateaued at gamma frequencies. Cells exposed to CAR showed significantly higher frequencies early in development compared with those without CAR (24.6 ± 3.8 vs. 41.7 ± 4.3 Hz, P < 0.001) but plateaued with age. The P/Q-type calcium channel blocker ω-agatoxin-IVA (ω-Aga) blocked gamma oscillations, whereas the N-type blocker ω-conotoxin-GVIA (ω-CgTx) only partially decreased the power spectrum amplitude of gamma oscillations. The blocking effect of ω-Aga on P/Q-type currents and ω-CgTx on N-type currents was consistent over age. We conclude that P/Q- and N-type calcium channels appear to mediate Pf gamma oscillations during development. We hypothesize that the cholinergic input to the Pf could activate these cells to oscillate at gamma frequency, and perhaps relay these rhythms to cortical areas, thus providing a stable high-frequency state for “nonspecific” thalamocortical processing.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Physiological Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Parafascicular
dc.subject
Arousal
dc.subject
Calcium Currents
dc.subject
Gamma Oscillations
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Gamma band activity in the developing parafascicular nucleus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-12T14:52:14Z
dc.journal.volume
107
dc.journal.number
3
dc.journal.pagination
772-784
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Kezunovic, Nebojsa. University Of Arkansas For Medical Sciences; Estados Unidos
dc.description.fil
Fil: Hyde, James. University Of Arkansas For Medical Sciences; Estados Unidos
dc.description.fil
Fil: Simon, Christen. University Of Arkansas For Medical Sciences; Estados Unidos
dc.description.fil
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Williams, D. Keith. University Of Arkansas For Medical Sciences; Estados Unidos
dc.description.fil
Fil: Garcia Rill, Edgar. University Of Arkansas For Medical Sciences; Estados Unidos
dc.journal.title
Journal of Neurophysiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1152/jn.00677.2011
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://jn.physiology.org/content/107/3/772
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289474/
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