Artículo
Mechanisms of the sperm guidance, an essential aid for meeting the oocyte
Lottero Leconte, Raquel; Alonso, Carlos Agustín Isidro
; Castellano, Luciana Andrea; Perez Martinez, Silvina Laura
Fecha de publicación:
03/2017
Editorial:
AME Publishing
Revista:
Translational Cancer Research
ISSN:
2218-676X
e-ISSN:
2219-6803
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In mammals, ejaculated spermatozoa must migrate into the female reproductive tract in order to reach and fertilize the oocyte (Figure 1). The number of spermatozoa that reach the oviductal isthmus (where they attach to oviductal cells and form the sperm reservoir) is small (1,2) and only ~10% of these spermatozoa in humans become capacitated (3) and acquire a state of readiness for fertilizing the oocyte. In addition, the sperm cells have a torturous and long way between the reservoir and the oocyte at the fertilization site (3–5 cm in humans) (2). These facts, together with the tiny dimensions of the gametes in comparison to the tube length make improbable the sperm arrival to the fertilization site and make evident the need for sperm guidance (4). Different guidance mechanisms appear essential for successful sperm arrival to the fertilization site: the short range mechanism such as chemotaxis (swimming up a chemoattractant gradient) (5) and the long range mechanisms such as rheotaxis (swimming against a fluid flow) and thermotaxis (the temperature-oriented cell motility).
Palabras clave:
Thermotaxis
,
Sperm Guidance
,
Trpv1
,
Fertility
Archivos asociados
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Identificadores
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Lottero Leconte, Raquel; Alonso, Carlos Agustín Isidro; Castellano, Luciana Andrea; Perez Martinez, Silvina Laura; Mechanisms of the sperm guidance, an essential aid for meeting the oocyte; AME Publishing; Translational Cancer Research; 6; Supl. 2; 3-2017; 1-4
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