Artículo
Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization
Fecha de publicación:
04/2012
Editorial:
Elsevier Science
Revista:
Journal of Pharmaceutical and Biomedical Analysis
ISSN:
0731-7085
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A complex of sulfamethoxazole (SMX) and hydroxypropyl-β-cyclodextrin (HP-β-CD) was developed and characterized in order to investigate their interactions in aqueous solution and the solid state. The SMX solubility was significantly increased upon complexation with HP-β-CD, with the solubility isotherm being an AN type due to the presence of aggregates and the stability constant calculated for a 1:1 complex being 302±3M-1. Fourier-transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) experiments were used to compare the freeze-dried system with a physical mixture, and demonstrated the complex formation in the solid state. The differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) showed that the thermal stability of SMX was enhanced in the presence of HP-β-CD.
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Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Garnero, Claudia; Aiassa, Virginia; Longhi, Marcela Raquel; Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 63; 4-2012; 74-79
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