Evento
Serotonin (5-HT) and catecholamines (CA) antagonistic food-related behaviors in C. elegans
Tipo del evento:
Congreso
Nombre del evento:
XXXIV Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias (SAN)
Fecha del evento:
03/10/2019
Institución Organizadora:
Sociedad Argentina de Investigación en Neurociencias;
Título del Libro:
SAN Sociedad Argentina de Investigación en Neurociencias
Editorial:
Sociedad Argentina de Investigación en Neurociencias
Idioma:
Inglés
Clasificación temática:
Resumen
Despite the intermodulation between serotonergic and adrenergic signals is crucial throughout the animal kingdom, the molecular and cellular mechanisms underlying this interrelation are poorly understood. We here use C. elegans as a model to get insights into the neural circuits linking 5-TH and CA. When food-deprived worms encounter food, 5-HT is released to slow-down their locomotion and to stimulate pharyngeal pumping.In contrast, exogenous Tyramine (TA) and Octopamine (OA), invertebrate counterparts for adrenaline and noradrenaline, stimulate locomotion and decreases pharyngeal pumping. We found that tdc-1 mutants (unable to synthesize TA and OA) are hypersensitive to 5-HT-mediated paralysis, suggesting that TA and OA acts antagonistically to 5-HT. We also identify the TA (TYRA-3) and OA (SER-3 and SER-6) receptors involved in this antagonism. Moreover, our calcium imaging recordings showed that the peak of activity of serotoninergic neurons upon encountering food is significantly higher in tdc-1 null mutant background. Taken together these results suggest that TA and OA counteract serotoninergic signaling by driving opposing behaviors and by inhibiting 5-HT release. Our final aim is to decipher the neural circuit and the molecules involved in the reciprocal modulation between CA and 5-HT in C. elegans. Given the conservation in molecular components of these pathways, our studies are likely significant to understand this interrelation in other animals.
Palabras clave:
BIOGENIC AMINES
,
ANTAGONISM
,
NEURONAL ACTIVITY
,
FOOD
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Eventos(INIBIBB)
Eventos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Eventos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Citación
Serotonin (5-HT) and catecholamines (CA) antagonistic food-related behaviors in C. elegans; XXXIV Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias (SAN); Villa Carlos Paz; Argentina; 2019; 43-43
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