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dc.contributor.author
Matturri, Luigi
dc.contributor.author
Milei, Jose
dc.contributor.author
Grana, Daniel Rodolfo
dc.contributor.author
Lavezzi, Anna Maria
dc.date.available
2022-12-21T12:52:21Z
dc.date.issued
2002-01
dc.identifier.citation
Matturri, Luigi; Milei, Jose; Grana, Daniel Rodolfo; Lavezzi, Anna Maria; Characterization of myocardial hypertrophy by DNA content, PCNA expression and apoptotic index; Elsevier Ireland; International Journal of Cardiology; 82; 1; 1-2002; 33-39
dc.identifier.issn
0167-5273
dc.identifier.uri
http://hdl.handle.net/11336/181923
dc.description.abstract
Background: At present little is known about the biological basis of cellular alterations in myocardial hypertrophy. The present study aims to analyze proliferating cell nuclear antigen (PCNA) expression, DNA content and apoptosis, in several types of myocardial hypertrophy in order to define the biological characteristics of this process. Methods: The biological parameters were investigated in normal hearts (n=4) and in 21 cases of left ventricular myocardial hypertrophy related to pressure overload (n=7), post-infarction remodeling (n=8) and hypertrophic cardiomyopathy (HCM) (n=8). Results: The analyzed biomarkers were similar in hypertension and in remodeling, with a very high apoptotic index (mean values: 8.1 and 8.5%, respectively), a low PCNA positivity (mean values: 1.8 and 1.6%) and a prevalent diploid DNA content (DNA index: 1.2). Conversely, HCM showed a high mean PCNA index (21.2%) associated with a prevalence of hyperdiploid myocytes (DNA index: 1.8) and a low number of apoptotic cells (mean value: 1.7%). Conclusions: There are significant biological differences between hypertrophy in HCM and that related to arterial hypertension and post-infarction remodeling. Therefore, the combined evaluation of DNA content, PCNA and apoptotic indices could provide a powerful diagnostic tool in doubtful cases of myocardial primary or secondary hypertrophy and open new avenues in the clinical treatment of these entities.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
APOPTOSIS
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DNA
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MYOCARDIAL HYPERTROPHY
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PROLIFERATING CELL NUCLEAR ANTIGEN
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Sistemas Cardíaco y Cardiovascular
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Characterization of myocardial hypertrophy by DNA content, PCNA expression and apoptotic index
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-11T19:47:05Z
dc.journal.volume
82
dc.journal.number
1
dc.journal.pagination
33-39
dc.journal.pais
Irlanda
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Matturri, Luigi. Università degli Studi di Milano; Italia
dc.description.fil
Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
dc.description.fil
Fil: Grana, Daniel Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad del Salvador; Argentina
dc.description.fil
Fil: Lavezzi, Anna Maria. Università degli Studi di Milano; Italia
dc.journal.title
International Journal of Cardiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0167527301005782
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/S0167-5273(01)00578-2
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