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dc.contributor.author
Caparotta, Marcelo Rubén
dc.contributor.author
Puiatti, Marcelo
dc.contributor.author
Masone, Diego Fernando
dc.date.available
2022-10-25T18:55:41Z
dc.date.issued
2021-08
dc.identifier.citation
Caparotta, Marcelo Rubén; Puiatti, Marcelo; Masone, Diego Fernando; Artificial stabilization of the fusion pore by intra-organelle styrene-maleic acid copolymers; Royal Society of Chemistry; Soft Matter; 17; 36; 8-2021; 8314-8321
dc.identifier.issn
1744-683X
dc.identifier.uri
http://hdl.handle.net/11336/174830
dc.description.abstract
Styrene-maleic acid copolymers have become an advantageous detergent-free alternative for membrane protein isolation. Since their discovery, experimental membrane protein extraction and purification by keeping intact their lipid environment has become significantly easier. With the aim of identifying new applications of these interesting copolymers, their molecular binding and functioning mechanisms have recently become intense objects of study. In this work, we describe the use of styrene-maleic acid copolymers as an artificial tool to stabilize the fusion pore. We show that when these copolymers circumscribe the water channel that defines the fusion pore, they keep it from shrinking and closing. We describe how only intra-organelle copolymers have stabilizing capabilities while extra-organelle ones have negligible or even contrary effects on the fusion pore life-time.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
SMA COPOLYMERS
dc.subject
FUSION PORE
dc.subject
ARTIFICIAL STABILIZATION
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Artificial stabilization of the fusion pore by intra-organelle styrene-maleic acid copolymers
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-22T00:27:55Z
dc.journal.volume
17
dc.journal.number
36
dc.journal.pagination
8314-8321
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Caparotta, Marcelo Rubén. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Puiatti, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.description.fil
Fil: Masone, Diego Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Cuyo. Facultad de Ingeniería; Argentina
dc.journal.title
Soft Matter
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2021/SM/D1SM00978H
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/D1SM00978H
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