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dc.contributor.author
Hermann, Romina
dc.contributor.author
Mestre Cordero, Victoria Evangelina
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Fernández Pazos, María de Las Mercedes
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Córdoba, Mailen Florencia
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Reznik, Federico Joaquín
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Vélez, Débora Elisabet
dc.contributor.author
Fellet, Andrea L.
dc.contributor.author
Marina Prendes, María Gabriela
dc.date.available
2022-10-17T11:12:24Z
dc.date.issued
2021-02
dc.identifier.citation
Hermann, Romina; Mestre Cordero, Victoria Evangelina; Fernández Pazos, María de Las Mercedes; Córdoba, Mailen Florencia; Reznik, Federico Joaquín; et al.; Role of AMPK in the protective effects exerted by triiodothyronine in ischemic-reperfused myocardium; BioScientifica; Journal of Molecular Endocrinology; 66; 3; 2-2021; 207-221
dc.identifier.issn
0952-5041
dc.identifier.uri
http://hdl.handle.net/11336/173405
dc.description.abstract
Recent studies have provided evidence that triiodothyronine (T3) might play an effective role in the recovery of ischemic myocardium, through the preservation of mitochondrial function and the improvement of energy substrate metabolism. To this respect, it has been suggested that T3 could activate AMP-activated protein kinase (AMPK), the cellular ‘fuel-gauge’ enzyme, although its role has yet to be elucidated. The aim of the present study was to investigate the effects produced by acute treatment with T3 (60 nM) and the pharmacological inhibition of AMPK by compound C on isolated rat left atria subjected to 75 min simulated ischemia-75 min reperfusion. Results showed that T3 increased AMPK activation during simulated ischemia-reperfusion, while compound C prevented it. At the end of simulated reperfusion, acute T3 treatment increased contractile function recovery and cellular viability conservation. Mitochondrial ultrastructure was better preserved in the presence of T3 as well as mitochondrial ATP production rate and tissue ATP content. Calcium retention capacity, a parameter widely used as an indicator of the resistance of mitochondrial permeability transition pore (MPTP) to opening, and GSK-3β phosphorylation, a master switch enzyme that limits MPTP opening, were increased by T3 administration. All these beneficial effects exerted by T3 acute treatment were prevented when compound C was co-administrated. The present study provided original evidence that T3 enhances intrinsic activation of AMPK during myocardial ischemiareperfusion, being this enzyme involved, at least in part, in the protective effects exerted by T3, contributing to mitochondrial structure and function preservation, post-ischemic contractile recovery and conservation of cellular viability.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioScientifica
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AMP-ACTIVATED PROTEIN KINASE
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CARDIPROTECTION
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COMPOUND C
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MYOCARDIUM
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SIMULATED ISCHEMIAREPERFUSION
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TRIIODOTHYRONINE
dc.subject.classification
Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Role of AMPK in the protective effects exerted by triiodothyronine in ischemic-reperfused myocardium
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-21T16:55:31Z
dc.journal.volume
66
dc.journal.number
3
dc.journal.pagination
207-221
dc.journal.pais
Reino Unido
dc.journal.ciudad
Bristol
dc.description.fil
Fil: Hermann, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil
Fil: Mestre Cordero, Victoria Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil
Fil: Fernández Pazos, María de Las Mercedes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; Argentina
dc.description.fil
Fil: Córdoba, Mailen Florencia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; Argentina
dc.description.fil
Fil: Reznik, Federico Joaquín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; Argentina
dc.description.fil
Fil: Vélez, Débora Elisabet. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil
Fil: Fellet, Andrea L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil
Fil: Marina Prendes, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.journal.title
Journal of Molecular Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://jme.bioscientifica.com/view/journals/jme/aop/jme-20-0314/jme-20-0314.xml
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1530/JME-20-0314
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