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dc.contributor.author
Rinaldini, Estefanía
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Campo Verde Arbocco, Fiorella
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Ezquer, Eduardo Marcelo
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Gamarra Luques, Carlos Diego
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Hapon, María Belén
dc.date.available
2022-10-13T19:27:24Z
dc.date.issued
2021-07
dc.identifier.citation
Rinaldini, Estefanía; Campo Verde Arbocco, Fiorella; Ezquer, Eduardo Marcelo; Gamarra Luques, Carlos Diego; Hapon, María Belén; Effect of Thyromimetic GC-1 Selective Signaling on Reproductive and Lactational Performance in the Hypothyroid Rat; Karger Publishers; European Thyroid Journal; 10; 5; 7-2021; 425-433
dc.identifier.issn
2235-0802
dc.identifier.uri
http://hdl.handle.net/11336/173115
dc.description.abstract
Introduction: The potential of the thyroid hormone receptor β (TRβ1) selective analog GC-1 has been widely proven in animal models and humans. However, its effect on the reproductive stage of the female rat has not been evaluated. Methods: The effect of the administration of GC-1 or equimolar doses of triiodothyronine (T3) was evaluated on the reproductive performance of the hypothyroid female rat and the indirect effect on pup thyroid status, weight, and survival. Results: Hypothyroidism reduced the number of embryos implanted in the uterus, whereas T3 and GC-1 treatment in hypothyroid females reestablished the number of implanted embryos to normal. Initiation of labor was delayed by hypothyroidism, and T3 replacement treatment reinstated the normal timing of parturition. The administration of GC-1 alone to the lactating mother did not affect pup survival, weight, or thyroidal status. Conclusions: Our findings show the differential effect of thyroid hormone selective signaling during gestation and the indirect exposure of the pups; we also emphasize the plausible use of GC-1 for treatment of hypothyroid mothers during the lactation period.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger Publishers
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GC-1
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GESTATION
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HYPOTHYROIDISM
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LACTATION
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PUP SURVIVAL
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Biología Reproductiva
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Effect of Thyromimetic GC-1 Selective Signaling on Reproductive and Lactational Performance in the Hypothyroid Rat
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-20T18:46:55Z
dc.journal.volume
10
dc.journal.number
5
dc.journal.pagination
425-433
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Rinaldini, Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Campo Verde Arbocco, Fiorella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Ezquer, Eduardo Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
dc.description.fil
Fil: Gamarra Luques, Carlos Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Hapon, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
European Thyroid Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://etj.bioscientifica.com/view/journals/etj/10/5/ETJ516432.xml
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000516432
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