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dc.contributor.author
Legaz, Agustina
dc.contributor.author
Abrevaya, Sofia
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Dottori, Martín
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Campo, Cecilia González
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Birba, Agustina
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Martorell Caro, Miguel Angel
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Aguirre, María Julieta
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Slachevsky, Andrea
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Aranguiz, Rafael
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Serrano, Cecilia Mariela
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Gillan, Claire M.
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Leroi, Iracema
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García, Adolfo Martín
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Fittipaldi, Sol
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Ibañez, Agustin Mariano
dc.date.available
2022-10-03T16:44:15Z
dc.date.issued
2021-03
dc.identifier.citation
Legaz, Agustina; Abrevaya, Sofia; Dottori, Martín; Campo, Cecilia González; Birba, Agustina; et al.; Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases; Oxford University Press; Brain; 145; 3; 3-2021; 1052-1068
dc.identifier.issn
0006-8950
dc.identifier.uri
http://hdl.handle.net/11336/171513
dc.description.abstract
Social feedback can selectively enhance learning in diverse domains. Relevant neurocognitive mechanisms have been studied mainly in healthy persons, yielding correlational findings. Neurodegenerative lesion models, coupled with multimodal brain measures, can complement standard approaches by revealing direct multidimensional correlates of the phenomenon. To this end, we assessed socially reinforced and non-socially reinforced learning in 40 healthy participants as well as persons with behavioural variant frontotemporal dementia (n = 21), Parkinson's disease (n = 31) and Alzheimer's disease (n = 20). These conditions are typified by predominant deficits in social cognition, feedback-based learning and associative learning, respectively, although all three domains may be partly compromised in the other conditions. We combined a validated behavioural task with ongoing EEG signatures of implicit learning (medial frontal negativity) and offline MRI measures (voxel-based morphometry). In healthy participants, learning was facilitated by social feedback relative to non-social feedback. In comparison with controls, this effect was specifically impaired in behavioural variant frontotemporal dementia and Parkinson's disease, while unspecific learning deficits (across social and non-social conditions) were observed in Alzheimer's disease. EEG results showed increased medial frontal negativity in healthy controls during social feedback and learning. Such a modulation was selectively disrupted in behavioural variant frontotemporal dementia. Neuroanatomical results revealed extended temporo-parietal and fronto-limbic correlates of socially reinforced learning, with specific temporo-parietal associations in behavioural variant frontotemporal dementia and predominantly fronto-limbic regions in Alzheimer's disease. In contrast, non-socially reinforced learning was consistently linked to medial temporal/hippocampal regions. No associations with cortical volume were found in Parkinson's disease. Results are consistent with core social deficits in behavioural variant frontotemporal dementia, subtle disruptions in ongoing feedback-mechanisms and social processes in Parkinson's disease and generalized learning alterations in Alzheimer's disease. This multimodal approach highlights the impact of different neurodegenerative profiles on learning and social feedback. Our findings inform a promising theoretical and clinical agenda in the fields of social learning, socially reinforced learning and neurodegeneration.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALZHEIMER'S DISEASE
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BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIA
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LEARNING
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PARKINSON'S DISEASE
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SOCIAL REINFORCEMENT
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-19T10:20:56Z
dc.journal.volume
145
dc.journal.number
3
dc.journal.pagination
1052-1068
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Córdoba; Argentina
dc.description.fil
Fil: Abrevaya, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
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Fil: Dottori, Martín. Universidad de San Andrés; Argentina
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Fil: Campo, Cecilia González. Universidad de San Andrés; Argentina
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Fil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina
dc.description.fil
Fil: Martorell Caro, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
dc.description.fil
Fil: Aguirre, María Julieta. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
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Fil: Slachevsky, Andrea. Universidad de Chile.; Chile
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Fil: Aranguiz, Rafael. Instituto Nacional de Geriatría; Chile
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Fil: Serrano, Cecilia Mariela. Unidad Asistencial "Dr. César Milstein"; Argentina
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Fil: Gillan, Claire M.. University of California; Estados Unidos
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Fil: Leroi, Iracema. University of California; Estados Unidos
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Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Trinity College; Estados Unidos. Universidad Nacional de Cuyo; Argentina. Universidad de Santiago de Chile; Chile
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Fil: Fittipaldi, Sol. Universidad de San Andrés; Argentina
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Fil: Ibañez, Agustin Mariano. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Trinity College; Estados Unidos. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Brain
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awab345/6371182
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/brain/awab345
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