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dc.contributor.author
Jáuregui, Ignacio Oscar
dc.contributor.author
Costanzo, Elsa Y.
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de Achaval, Delfina
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Villarreal, Mirta Fabiana
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Chu, Elvina
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Mora, Martina C.
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Vigo, Daniel Eduardo
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Castro, Mariana Nair
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Leiguarda, Ramón C.
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Bär, Karl-Jürgen
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Guinjoan, Salvador Martín
dc.date.available
2017-05-12T15:57:58Z
dc.date.issued
2011-12
dc.identifier.citation
Jáuregui, Ignacio Oscar; Costanzo, Elsa Y.; de Achaval, Delfina; Villarreal, Mirta Fabiana; Chu, Elvina; et al.; Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives; Lippincott Williams ; Cognitive And Behavioral Neurology; 24; 4; 12-2011; 194-203
dc.identifier.issn
1543-3633
dc.identifier.uri
http://hdl.handle.net/11336/16382
dc.description.abstract
Objective: To determine if patients with schizophrenia and their unaffected first degree relatives have abnormal autonomic nervous system (ANS) responses to social cognition tasks. Background: Social cognition impairments are significant in schizophrenia. ANS activity has been shown to be abnormal in schizophrenia patients, and some of these abnormalities seem to be shared by unaffected relatives of afflicted persons. Method: Heart rate variability (HRV) was measured at rest, and while performing social cognition tasks in patients with schizophrenia, their nonpsychotic firstdegree relatives, and matched healthy persons (n=19 in each group). Results: Social cognition tasks induced a shortening of the RR interval in unaffected relatives, but not in patients. Social cognition tasks generated decreases in high-frequency (HF, indicative of cardiac vagal activity) and in low frequency (LF, reflecting predominantly sympathetic activity) HRV in patients, while in relatives the decrease occurred in The HF component only. LF-HRV was higher in patients during a theory of mind task compared with a control task. These changes were not observed in healthy persons. Conclusions: Social cognitive tasks induce a pattern of peripheral autonomic activity different from that seen in generic arousal responses, and such pattern is abnormal in schizophrenia patients. Autonomic abnormalities in unaffected first degree relatives seem restricted to the parasympathetic division of the ANS.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Schizophrenia
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Social Cognition
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Autonomic Nervous System
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Endophenotype
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Psiquiatría
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-05-10T20:34:09Z
dc.journal.volume
24
dc.journal.number
4
dc.journal.pagination
194-203
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Filadelfia
dc.description.fil
Fil: Jáuregui, Ignacio Oscar. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
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Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
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Fil: de Achaval, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
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Fil: Chu, Elvina. University College London; Estados Unidos
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Fil: Mora, Martina C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
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Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de Los Buenos Aires"; Argentina
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Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Leiguarda, Ramón C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Bär, Karl-Jürgen. Universitat Jena; Alemania
dc.description.fil
Fil: Guinjoan, Salvador Martín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
dc.journal.title
Cognitive And Behavioral Neurology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/cogbehavneurol/pages/articleviewer.aspx?year=2011&issue=12000&article=00004&type=abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/WNN.0b013e31824007e9
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