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dc.contributor.author
Nooeaid, Patcharakamon
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Li, Wei
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Roether, Judith A.
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Mouriño, Viviana Silvia Lourdes
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Goudouri, Ourania Menti
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Schubert, Dirk W.
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Boccaccini, Aldo R.
dc.date.available
2017-05-08T22:08:44Z
dc.date.issued
2014-10
dc.identifier.citation
Nooeaid, Patcharakamon; Li, Wei; Roether, Judith A.; Mouriño, Viviana Silvia Lourdes; Goudouri, Ourania Menti; et al.; Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating; Avs; Biointerphases; 9; 4; 10-2014; 1-10
dc.identifier.issn
1934-8630
dc.identifier.uri
http://hdl.handle.net/11336/16123
dc.description.abstract
Highly porous 45S5 Bioglass®-based scaffolds coated with two polymer layers were fabricated to serve as a multifunctional device with controlled drug release capability for bone regeneration applications. An interior poly(d,l-lactide)/poly(ethylene glycol)-(polypropylene glycol)-poly(ethylene glycol) triblock copolymer (Pluronic P123) coating improved the mechanical stability of Bioglass-based scaffolds, while an exterior natural polymer (alginate or gelatin) coating served as an antibiotic drug carrier. The results showed improved mechanical properties of Bioglass-based scaffolds by the bilayer polymer coating. In addition, hydrochloride tetracycline loaded in either alginate or gelatin coatings was released rapidly at the initial stage (∼1 h), while the released rate subsequently decreased and was sustained for 14 days in phosphate buffered saline. Therefore, these layered polymer coated scaffolds exhibit attractive characteristics in terms of improved mechanical properties and controlled drug release, simultaneously with the added advantage that the drug release rate is decoupled from the intrinsic scaffold Bioglass degradation mechanism. The layered polymer coated scaffolds are of interest for drug-delivery enhanced bone regeneration applications.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Avs
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bioactive Glass Based Scaffolds
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Controlled Release
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Bone Tissue Engineering
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Polymer Layered Coatings
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Otras Ingeniería de los Materiales
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Ingeniería de los Materiales
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INGENIERÍAS Y TECNOLOGÍAS
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Otras Ciencias Médicas
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Otras Ciencias Médicas
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-26T14:13:42Z
dc.identifier.eissn
1559-4106
dc.journal.volume
9
dc.journal.number
4
dc.journal.pagination
1-10
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Nooeaid, Patcharakamon. Universitat Erlangen-Nuremberg; Alemania
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Fil: Li, Wei. Universitat Erlangen-Nuremberg; Alemania
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Fil: Roether, Judith A.. Universitat Erlangen-Nuremberg; Alemania
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Fil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Goudouri, Ourania Menti. Universitat Erlangen-Nuremberg; Alemania
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Fil: Schubert, Dirk W.. Universitat Erlangen-Nuremberg; Alemania
dc.description.fil
Fil: Boccaccini, Aldo R.. Universitat Erlangen-Nuremberg; Alemania
dc.journal.title
Biointerphases
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1116/1.4897217
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://avs.scitation.org/doi/10.1116/1.4897217
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