Mostrar el registro sencillo del ítem
dc.contributor.author
Momper, Jeremiah D.
dc.contributor.author
Hanan, Nathan J.
dc.contributor.author
Rossi, Steven S.
dc.contributor.author
Mirochnick, Mark H.
dc.contributor.author
Cafferata, Maria Luisa
dc.contributor.author
Lavenia, Antonia
dc.contributor.author
Flores, Isolina
dc.contributor.author
Gibbons, Luz
dc.contributor.author
Ciganda, Alvaro
dc.contributor.author
Sosa-Estani, Sergio Alejandro
dc.contributor.author
Capparelli, Edmund V.
dc.contributor.author
Buekens, Pierre
dc.date.available
2021-12-03T12:50:28Z
dc.date.issued
2019-07
dc.identifier.citation
Momper, Jeremiah D.; Hanan, Nathan J.; Rossi, Steven S.; Mirochnick, Mark H.; Cafferata, Maria Luisa; et al.; Determination of benznidazole in human dried blood spots by liquid chromatography-mass spectrometry to monitor adherence to trypanosoma cruzi infection treatment in infants and children; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 101; 1; 7-2019; 116-122
dc.identifier.issn
0002-9637
dc.identifier.uri
http://hdl.handle.net/11336/148047
dc.description.abstract
Medication adherence is critical to the effectiveness of benznidazole (BZ) therapy for the treatment of Chagas disease. Assessing BZ adherence using traditional plasma sampling methods presents numerous challenges in resource-limited settings. Dried blood spot (DBS) sampling ofBZcan be used to overcome logistical barriers and provides a less invasive method for assessing BZ levels. ABZDBSassay using liquid chromatography-tandem mass spectrometry was developed and applied to a clinical study of infants and children being treated withBZ for Trypanosoma cruzi infection in Argentina. The assay was validated over a concentration range of 9.8-5,000 ng/mL. Inter-assay and intra-assay measures ranged from -2.9% to 2.7% and 0.5% to 8.3% for accuracy and from 3.5% to 12% and 1.6% to 13.6% for precision, respectively. The mean recovery of BZ was greater than 91%. Partitioning ratios for DBSs/plasma ranged from 0.95 to 1.02. A cohort of 10 infants and six children with T. cruzi infection being treated with BZ had median BZ concentrations of 1.2 (IQR 0.29, 2.14) μg/mL with seven of 65 (11%) samples above the BZ treatment goal of 3 μg/mL for adults. The reported DBS assay is a simple and accurate method for the quantitative measurement of BZ that can be applied to facilitate urgently needed clinical studies of BZfor the treatment of Chagas disease and assessBZadherence in resource-limited settings.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society of Tropical Medicine and Hygiene
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Chagas disease
dc.subject
Pharmacokinetic
dc.subject
Treatment
dc.subject.classification
Otras Medicina Clínica
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Determination of benznidazole in human dried blood spots by liquid chromatography-mass spectrometry to monitor adherence to trypanosoma cruzi infection treatment in infants and children
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-01-04T14:32:13Z
dc.journal.volume
101
dc.journal.number
1
dc.journal.pagination
116-122
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Momper, Jeremiah D.. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Hanan, Nathan J.. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Rossi, Steven S.. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Mirochnick, Mark H.. Boston University; Estados Unidos
dc.description.fil
Fil: Cafferata, Maria Luisa. No especifíca;
dc.description.fil
Fil: Lavenia, Antonia. Ministerio de Salud Pública de la Provincia de Tucumán; Argentina
dc.description.fil
Fil: Flores, Isolina. Ministerio de Salud Pública de la Provincia de Tucumán; Argentina
dc.description.fil
Fil: Gibbons, Luz. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.description.fil
Fil: Ciganda, Alvaro. No especifíca;
dc.description.fil
Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
dc.description.fil
Fil: Capparelli, Edmund V.. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Buekens, Pierre. University of Tulane; Estados Unidos
dc.journal.title
American Journal of Tropical Medicine and Hygiene
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4269/ajtmh.18-0852
Archivos asociados