Artículo
Higher congenital transmission rate of Trypanosoma cruzi associated with family history of congenital transmission
Fecha de publicación:
03/2020
Editorial:
Sociedade Brasileira de Medicina Tropical
Revista:
Revista Da Sociedade Brasileira de Medicina Tropical
ISSN:
0037-8682
e-ISSN:
1678-9849
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Introduction: Congenital transmission (CT) of Trypanosoma cruzi has led to globalization of Chagas disease and its growing relevance as a public health problem. Although the occurrence of CT has been associated with several factors, its mechanisms are still unknown. This study aimed to analyze the geographical and familiar variables of mothers and their association with CT of Chagas disease in a population living in non-endemic areas of Argentina for the last decades. Methods: We developed a retrospective cohort study in a sample of 2120 mother-child pairs who attended three reference centers in the cities of Buenos Aires, Santa Fe, and Salta between 2002 and 2015. Results: The highest CT rates were observed in children born to Argentinean mothers (10.7%) and in children born to mothers from Buenos Aires (11.7%). Considering the areas of origin of the mothers, those from areas of null-low risk for vector-borne infection had higher CT rates than those from areas of medium-high risk (11.1% vs 8.2%). We also observed a significant intra-familiar “cluster effect,” with CT rates of 35.9% in children with an infected sibling, compared to 8.2% in children without infected siblings (RR=4.4 95% CI 2.3-8.4). Conclusions: The associations observed suggest a higher CT rate in children born to mothers who acquired the infection congenitally, with familiar antecedents, and from areas without the presence of vectors. These observations are considered new epidemiological evidence about Chagas disease in a contemporary urban population, which may contribute to the study of CT and may also be an interesting finding for healthcare professionals.
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Articulos(CIESP)
Articulos de CENTRO DE INVESTIGACIONES EN EPIDEMIOLOGIA Y SALUD PUBLICA
Articulos de CENTRO DE INVESTIGACIONES EN EPIDEMIOLOGIA Y SALUD PUBLICA
Citación
Danesi, Emmaría; Fabbro, Diana Lucrecia; Segura, Elsa Leonor; Sosa-Estani, Sergio Alejandro; Higher congenital transmission rate of Trypanosoma cruzi associated with family history of congenital transmission; Sociedade Brasileira de Medicina Tropical; Revista Da Sociedade Brasileira de Medicina Tropical; 53; 3-2020; 1-7
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