Artículo
Induction of ischemic tolerance as a promising treatment against diabetic retinopathy
Fecha de publicación:
09/2014
Editorial:
Medknow Publications
Revista:
Neural Regeneration Research
ISSN:
1673-5374
e-ISSN:
1876-7958
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Diabetic retinopathy is a leading cause of acquired blindness, and it is the most common ischemic disorder of the retina. Available treatments are not very effective. Efforts to inhibit diabetic retinopathy have focused either on highly specific therapeutic approaches for pharmacologic targets or using genetic approaches to change expression of certain enzymes. However, it might be wise to choose innovative treatment modalities that act by multiple potential mechanisms. The resistance to ischemic injury, or ischemic tolerance, can be transiently induced by prior exposure to a non-injurious preconditioning stimulus. A complete functional and histologic protection against retinal ischemic damage can be achieved by previous preconditioning with non-damaging ischemia. In this review, we will discuss evidence that supports that ischemic conditioning could help avert the dreaded consequences that results from retinal diabetic damage.
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Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Rosenstein, Ruth Estela; Fernandez, Diego Carlos; Induction of ischemic tolerance as a promising treatment against diabetic retinopathy; Medknow Publications; Neural Regeneration Research; 9; 17; 9-2014; 1581-1584
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