Capítulo de Libro
Alzheimer Disease: A New Beginning or a Final Exit?
Título del libro: Cell Cycle Mechanisms and Neuronal Cell Death
Obrenovich, Mark E.; Raina, Arun K.; Ogawa, Osamu; Atwood, Craig S.; Morelli, Laura
; Smith, Mark A.
Fecha de publicación:
2005
Editorial:
Springer
ISBN:
978-0-306-47850-5
Idioma:
Inglés
Clasificación temática:
Resumen
Today, a new chapter is being written in the book of Alzheimer disease, one that is challenging the longstanding view that adult neurons are incapable of division, remain nonproliferative, and are terminally differentiated. Here, we review the provocative notion that, in Alzheimer disease, whole populations of nonstem cell neurons leave their quiescent state and re-enter into the cell cycle. However, such neuronal re-entry into the cell cycle is futile and ultimately leads to the neurodegeneration that typifies Alzheimer disease.
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Capítulos de libros(IIBBA)
Capítulos de libros de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Capítulos de libros de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Obrenovich, Mark E.; Raina, Arun K.; Ogawa, Osamu; Atwood, Craig S.; Morelli, Laura; et al.; Alzheimer Disease: A New Beginning or a Final Exit?; Springer; 2005; 79-93
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