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dc.contributor.author
Angelo, María Florencia
dc.contributor.author
Aviles Reyes, Rolando Xavier
dc.contributor.author
Villarreal, Alejandro
dc.contributor.author
Barker, Philip A.
dc.contributor.author
Reines, Analia Gabriela
dc.contributor.author
Ramos, Alberto Javier
dc.date.available
2021-05-31T13:19:38Z
dc.date.issued
2009-10
dc.identifier.citation
Angelo, María Florencia; Aviles Reyes, Rolando Xavier; Villarreal, Alejandro; Barker, Philip A.; Reines, Analia Gabriela; et al.; p75 NTR expression is induced in isolated neurons of the penumbra after ischemia by cortical devascularization; Wiley-liss, div John Wiley & Sons Inc.; Journal of Neuroscience Research; 87; 8; 10-2009; 1892-1903
dc.identifier.issn
0360-4012
dc.identifier.uri
http://hdl.handle.net/11336/132828
dc.description.abstract
The p75 neurotrophin receptor (p75NTR) is involved in neuronal functions going from induction of apoptosis and growth inhibition to the promotion of survival. p75NTR expression is induced in central nervous system (CNS) by a wide range of pathological conditions where it seems to have a main role in neuronal death and axonal growth inhibition. The cellular mechanisms driving p75NTR expression in cell lines and primary neurons in culture depend on Sp1-induced transcription (Ramos et al., 2007, J. Neurosci 27:1498). In this study we analyzed the spatio-temporal profile of p75NTR expression after a localized ischemic lesion in the rat brain induced by cortical devascularization (CD). Our results showed that p75NTR expression occurred in isolated neurons of the ischemic penumbra. The p75NTR+ neurons presented morphological alterations and active caspase-3 staining. Some of these p75NTR+ neurons were also positive for sortilin. The peak of p75NTR expression was localized 3 days after the lesion (3DPL), while abundance of Sp1 transcription factor increased from 3 to 14DPL on the lesioned hemisphere. In primary cortical neurons, we demonstrated that p75NTR expression is induced by excitotoxic stress and correlated with increased Sp1 abundance. We conclude that p75NTR expression is localized in selected neurons of the ischemic penumbra and these neurons are probably condemned to apoptotic cell death. In primary neuronal culture is clear that excitotoxity and Sp1 are involved in induction of p75NTR expression, although in vivo some additional mechanisms are likely to be involved in the control of the p75NTR expression in specific neurons in vivo.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, div John Wiley & Sons Inc.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GLUTAMATE
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ISCHEMIA
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NEURONAL DEATH
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NEUROTROPHIN
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SORTILIN
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SP1
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Otras Ciencias Médicas
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Otras Ciencias Médicas
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
p75 NTR expression is induced in isolated neurons of the penumbra after ischemia by cortical devascularization
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-11T19:44:39Z
dc.journal.volume
87
dc.journal.number
8
dc.journal.pagination
1892-1903
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Los Angeles
dc.description.fil
Fil: Angelo, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.description.fil
Fil: Aviles Reyes, Rolando Xavier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.description.fil
Fil: Villarreal, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.description.fil
Fil: Barker, Philip A.. McGill University; Canadá
dc.description.fil
Fil: Reines, Analia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.description.fil
Fil: Ramos, Alberto Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.journal.title
Journal of Neuroscience Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jnr.21993
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jnr.21993
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