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dc.contributor.author
Todorich, Bozho
dc.contributor.author
Pasquini, Juana Maria
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Garcia, Corina Ileana
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Paez, Pablo M.
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Connor, James R.
dc.date.available
2020-09-17T17:16:04Z
dc.date.issued
2009-04
dc.identifier.citation
Todorich, Bozho; Pasquini, Juana Maria; Garcia, Corina Ileana; Paez, Pablo M.; Connor, James R.; Oligodendrocytes and myelination: The role of iron; Veterinary and Human Toxicology; Glia; 57; 5; 4-2009; 467-478
dc.identifier.issn
0894-1491
dc.identifier.uri
http://hdl.handle.net/11336/114232
dc.description.abstract
Iron is an essential trophic factor that is required for oxygen consumption and ATP production. Thus it plays a key role in vital cell functions. Although the brain has a relatively high rate of oxygen consumption compared to other organs, oligodendrocytes are the principal cells in the CNS that stain for iron under normal conditions. The importance of iron in myelin production has been demonstrated by studies showing that decreased availability of iron in the diet is associated with hypomyelination. The timing of iron delivery to oligodendrocytes during development is also important because hypomyelination and the associated neurological sequelae persist long after the systemic iron deficiency has been corrected. Therefore, identifying the molecular roles of iron in oligodendrocyte development and myelin production, and the mechanisms and timing of iron acquisitions are important prerequisites to developing effective therapies for dysmyelinating disorders. It is the purpose of this review to give a comprehensive overview of the existing literature on role of iron in oligodendrocytes and the mechanisms of iron acquisition and intracellular handling.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Veterinary and Human Toxicology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DYSMYELINATING DISORDERS
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FERRITIN
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IRON
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METALS
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MYELIN
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OLIGODENDROCYTE DEVELOPMENT
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TRANSFERRIN
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Biología del Desarrollo
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Oligodendrocytes and myelination: The role of iron
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-08T14:04:23Z
dc.journal.volume
57
dc.journal.number
5
dc.journal.pagination
467-478
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva Jersey
dc.description.fil
Fil: Todorich, Bozho. Penn State College Of Medicine; Estados Unidos
dc.description.fil
Fil: Pasquini, Juana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
dc.description.fil
Fil: Garcia, Corina Ileana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
dc.description.fil
Fil: Paez, Pablo M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
dc.description.fil
Fil: Connor, James R.. Penn State College Of Medicine; Estados Unidos
dc.journal.title
Glia
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.20784
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1002/glia.20784
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