Artículo
Constitutive description of skin dermis: Through analytical continuum and coarse-grained approaches for multi-scale understanding
Fecha de publicación:
01/2020
Editorial:
Elsevier
Revista:
Acta Biomaterialia
ISSN:
1742-7061
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Although there are many successful descriptions of the mechanical response of dermis at different levels of complexity and incorporating varying degrees of the physical phenomena involved in deformation, observations indicate that the unraveling of fibers involves a complex three-dimensional process in which they interact in ways that resemble a braided pattern. Here we develop two complementary treatments to gain a better understanding of the mechanical response of dermis: a) an analytical treatment incorporating fibril stiffness, interfibrillar frictional sliding, and the effect of lateral fibers on the extension of a primary fiber; b) a coarse-grained molecular dynamics model comprised of an array of parallel curved fibrils simulating a fiber. Interfibrillar frictional sliding and stiffness are also captured. Both analytical and molecular dynamics models operate at a scale compatible with the wavelength of collagen fibers (~10 μm). The constitutive description presented here incorporates important physical processes taking place during deformation of dermis and thus represents an advance in our understanding of these phenomena.
Palabras clave:
COARSE GRAIN MODELING
,
COLLAGEN
,
CONSTITUTIVE MODELING
,
MOLECULAR DYNAMICS
,
SKIN
Archivos asociados
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Identificadores
Colecciones
Articulos(ICB)
Articulos de INSTITUTO INTERDISCIPLINARIO DE CIENCIAS BASICAS
Articulos de INSTITUTO INTERDISCIPLINARIO DE CIENCIAS BASICAS
Citación
Pissarenko, Andrei; Ruestes, Carlos Javier; Meyers, Marc A.; Constitutive description of skin dermis: Through analytical continuum and coarse-grained approaches for multi-scale understanding; Elsevier; Acta Biomaterialia; 106; 1; 1-2020; 208-224
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