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dc.contributor.author
Bomben, Riccardo
dc.contributor.author
Roisman, Alejandro
dc.contributor.author
D'Agaro, Tiziana
dc.contributor.author
Castellano, Giancarlo
dc.contributor.author
Baumann, Tycho
dc.contributor.author
Delgado, Julio
dc.contributor.author
López Guillermo, Armando
dc.contributor.author
Zucchetto, Antonella
dc.contributor.author
Dal Bo, Michele
dc.contributor.author
Bravin, Vanessa
dc.contributor.author
Slavutsky, Irma Rosa
dc.contributor.author
Vlasova, Anna
dc.contributor.author
Guigó, Roderic
dc.contributor.author
Martin Subero, Jose I.
dc.contributor.author
Chapaprieta, Vicente
dc.contributor.author
Beekman, Renee
dc.contributor.author
Martin García, David
dc.contributor.author
Beà, Sílvia
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Salaverria, Itziar
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Aymerich, Marta
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Campo, Elias
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Gattei, Valter
dc.contributor.author
Hernández, Luis
dc.date.available
2020-08-03T06:56:34Z
dc.date.issued
2019-03
dc.identifier.citation
Bomben, Riccardo; Roisman, Alejandro; D'Agaro, Tiziana; Castellano, Giancarlo; Baumann, Tycho; et al.; Expression of the transcribed ultraconserved region 70 and the related long non-coding RNA AC092652.2-202 has prognostic value in Chronic Lymphocytic Leukaemia; Wiley Blackwell Publishing, Inc; British Journal of Haematology; 184; 6; 3-2019; 1045-1050
dc.identifier.issn
0007-1048
dc.identifier.uri
http://hdl.handle.net/11336/110734
dc.description.abstract
Chronic lymphocytic leukemia (CLL) development and progression is known to be affected by a plethora of external signals. Among the receptors sensitive to such stimuli, toll-like receptor 9 (TLR9) is of interest because treatment with an agonist like CpG-oligodeoxynucleotide (CpG-ODN) impacts in tumor cell viability and immunogenicity through rendering them more sensitive to T cell-mediated cytotoxicity and chemotherapeutic agents in vitro. Long non-coding RNA (lncRNA) expression alterations have been implicated in various neoplasms including CLL, suggesting that they could also be therapeutic targets and/or clinically useful biomarkers. Transcribed Ultraconserved Regions (T-UCRs) are a class of lncRNA comprising a total of 481 different transcripts with an absolute degree of conservation among human, mouse and rat, that it is suggestive of an essential functional relevance in mammals. In the present study we have explored the possible role of T-UCR in the pathogenesis of CLL performing a global screening using microarrays and qRT-PCR in response to CpG-ODN stimulation. We have identified a AC092652.2-202 as the uc.70-related lncRNA which expression levels are related to the response to CpG-ODN and have prognostic significance in CLL. These findings warrant further studies on the functional characterization of this lncRNA in CLL as well of the particular role of uc.70 sequence in its expression regulation
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHRONIC LYMPHOCYTIC LEUKEMIA
dc.subject
T-UCR
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GENE EXPRESSION
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PROGNOSTIC FACTORS
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Genética Humana
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Expression of the transcribed ultraconserved region 70 and the related long non-coding RNA AC092652.2-202 has prognostic value in Chronic Lymphocytic Leukaemia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-23T19:29:19Z
dc.journal.volume
184
dc.journal.number
6
dc.journal.pagination
1045-1050
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Bomben, Riccardo. University of Miami; Estados Unidos. Centro Di Riferimento Oncologico; Italia
dc.description.fil
Fil: Roisman, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Lymphoid Neoplasm Program; España. University of Miami; Estados Unidos
dc.description.fil
Fil: D'Agaro, Tiziana. Centro Di Riferimento Oncologico; Italia
dc.description.fil
Fil: Castellano, Giancarlo. Hospital Clínico de Barcelona; España
dc.description.fil
Fil: Baumann, Tycho. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Lymphoid Neoplasm Program; España. Hospital Clínico de Barcelona; España
dc.description.fil
Fil: Delgado, Julio. Hospital Clínico de Barcelona; España. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Lymphoid Neoplasm Program; España
dc.description.fil
Fil: López Guillermo, Armando. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Lymphoid Neoplasm Program; España. Hospital Clínico de Barcelona; España
dc.description.fil
Fil: Zucchetto, Antonella. Centro Di Riferimento Oncologico; Italia
dc.description.fil
Fil: Dal Bo, Michele. Centro Di Riferimento Oncologico; Italia
dc.description.fil
Fil: Bravin, Vanessa. Centro Di Riferimento Oncologico; Italia
dc.description.fil
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Vlasova, Anna. Barcelona Institute Of Science And Technology.; España
dc.description.fil
Fil: Guigó, Roderic. Barcelona Institute Of Science And Technology.; España
dc.description.fil
Fil: Martin Subero, Jose I.. Centro de Investigación Biomédica en Red de Cáncer ; España. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Lymphoid Neoplasm Program; España
dc.description.fil
Fil: Chapaprieta, Vicente. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Lymphoid Neoplasm Program; España
dc.description.fil
Fil: Beekman, Renee. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Lymphoid Neoplasm Program; España. Centro de Investigación Biomédica en Red de Cáncer ; España
dc.description.fil
Fil: Martin García, David. Centro de Investigación Biomédica en Red de Cáncer ; España. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Lymphoid Neoplasm Program; España
dc.description.fil
Fil: Beà, Sílvia. Centro de Investigación Biomédica en Red de Cáncer ; España. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Lymphoid Neoplasm Program; España
dc.description.fil
Fil: Salaverria, Itziar. Centro de Investigación Biomédica en Red de Cáncer ; España. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Lymphoid Neoplasm Program; España
dc.description.fil
Fil: Aymerich, Marta. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Lymphoid Neoplasm Program; España. Hospital Clínico de Barcelona; España
dc.description.fil
Fil: Campo, Elias. Centro de Investigación Biomédica en Red de Cáncer ; España. Hospital Clínico de Barcelona; España. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Lymphoid Neoplasm Program; España
dc.description.fil
Fil: Gattei, Valter. Centro Di Riferimento Oncologico; Italia
dc.description.fil
Fil: Hernández, Luis. Centro de Investigación Biomédica en Red de Cáncer ; España. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Lymphoid Neoplasm Program; España
dc.journal.title
British Journal of Haematology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/bjh.15237
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.15237
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