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dc.contributor.author
Barchuk, Magalí
dc.contributor.author
Dutour, Anne
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Ancel, Patricia
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Svilar, Ljubica
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Miksztowicz, Verónica Julieta
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Lopez, Graciela
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Rubio Mas, Miguel Angel
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Schreier, Laura Ester
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Nogueira, Juan Patricio
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Valéro, René
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Béliard, Sophie
dc.contributor.author
Martin, Jean Charles
dc.contributor.author
Berg, Gabriela Alicia
dc.contributor.author
Gaborit, Bénédicte
dc.date.available
2020-07-08T19:45:35Z
dc.date.issued
2020-04-04
dc.identifier.citation
Barchuk, Magalí; Dutour, Anne; Ancel, Patricia; Svilar, Ljubica; Miksztowicz, Verónica Julieta; et al.; Untargeted Lipidomics Reveals a Specific Enrichment in Plasmalogens in Epicardial Adipose Tissue and a Specific Signature in Coronary Artery Disease; Lippincott Williams; Arteriosclerosis, Thrombosis, and Vascular Biology; 40; 4; 4-4-2020; 986-1000
dc.identifier.issn
1079-5642
dc.identifier.uri
http://hdl.handle.net/11336/109118
dc.description.abstract
OBJECTIVE:Epicardial adipose tissue (EAT) is an active endocrine organ that could contribute to the pathophysiology of coronary artery disease (CAD) through the paracrine release of proatherogenic mediators. Numerous works have analyzed the inflammatory signature of EAT, but scarce informations on its lipidome are available. Our objective was first to study the differences between EAT and subcutaneous adipose tissue (SAT) lipidomes and second to identify the specific untargeted lipidomic signatures of EAT and SAT in CAD. Approach and Results: Subcutaneous and EAT untargeted lipidomic analysis was performed in 25 patients with CAD and 14 patients without CAD and compared with paired plasma lipidomic analysis of isolated VLDL (very low-density lipoprotein) and HDL (high-density lipoprotein). Lipidomics was performed on a C18 column hyphenated to a Q-Exactive plus mass spectrometer, using both positive and negative ionization mode. EAT and SAT had independent lipidomic profile, with 95 lipid species differentially expressed and phosphatidylethanolamine 18:1p/22:6 twenty-fold more expressed in EAT compared with SAT false discovery rate =3×10-4). Patients with CAD exhibited more ceramides (P=0.01), diglycerides (P=0.004; saturated and nonsaturated), monoglycerides (P=0.013) in their EAT than patients without CAD. Conversely, they had lesser unsaturated TG (triglycerides; P=0.02). No difference was observed in the 295 lipid species found in SAT between patients with and without CAD. Fifty-one lipid species were found in common between EAT and plasma lipoproteins. TG 18:0/18:0/18:1 was found positively correlated (r=0.45, P=0.019) in EAT and HDL and in EAT and VLDL (r=0.46, P=0.02).CONCLUSIONS:CAD is associated with specific lipidomic signature of EAT, unlike SAT. Plasma lipoprotein lipidome only partially reflected EAT lipidome.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CORONARY ARTERY DISEASE
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EPICARDIAL ADIPOSE TISSUE
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LIPIDOMICS
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LIPOPROTEIN
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MASS SPECTROMETRY
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Untargeted Lipidomics Reveals a Specific Enrichment in Plasmalogens in Epicardial Adipose Tissue and a Specific Signature in Coronary Artery Disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-07-01T17:09:20Z
dc.journal.volume
40
dc.journal.number
4
dc.journal.pagination
986-1000
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Barchuk, Magalí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
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Fil: Dutour, Anne. Aix Marseille Universite; Francia
dc.description.fil
Fil: Ancel, Patricia. Aix Marseille Universite; Francia
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Fil: Svilar, Ljubica. Aix Marseille Universite; Francia
dc.description.fil
Fil: Miksztowicz, Verónica Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.description.fil
Fil: Lopez, Graciela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.description.fil
Fil: Rubio Mas, Miguel Angel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
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Fil: Nogueira, Juan Patricio. Hospital Central de Formosa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Valéro, René. Aix Marseille Universite; Francia
dc.description.fil
Fil: Béliard, Sophie. Aix Marseille Universite; Francia
dc.description.fil
Fil: Martin, Jean Charles. Aix Marseille Universite; Francia
dc.description.fil
Fil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Gaborit, Bénédicte. Aix Marseille Universite; Francia
dc.journal.title
Arteriosclerosis, Thrombosis, and Vascular Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.313955
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1161/ATVBAHA.120.313955
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