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dc.contributor.author
Gajewski, Thomas F.
dc.contributor.author
Fuertes, Mercedes Beatriz
dc.contributor.author
Spaapen, Robbert
dc.contributor.author
Zheng, Yan
dc.contributor.author
Kline, Justin
dc.date.available
2017-01-05T20:31:10Z
dc.date.issued
2011-04
dc.identifier.citation
Gajewski, Thomas F. ; Fuertes, Mercedes Beatriz; Spaapen, Robbert ; Zheng, Yan ; Kline, Justin ; Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment; Elsevier; Current Opinion In Immunology; 23; 2; 4-2011; 286-292
dc.identifier.issn
0952-7915
dc.identifier.uri
http://hdl.handle.net/11336/10891
dc.description.abstract
The molecular identification of tumor antigens initially catalyzed substantial enthusiasm for the development of tumor antigen-based vaccines for the treatment of cancer. However, numerous vaccine approaches in melanoma and other cancers have yielded a low rate of clinical response, despite frequent induction of specific T cells as detected in the peripheral blood. This observation has prompted several investigators to begin interrogating the tumor microenvironment for biologic correlates to tumor response versus resistance. Evidence is beginning to emerge suggesting that distinct subsets of tumors may exist that reflect distinct categories of immune escape. Lack of chemokine-mediated trafficking, poor innate immune cell activation, and the presence of specific immune suppressive mechanisms can be found to characterize subsets of tumors. A non-inflamed tumor phenotype may predict for resistance to cancer vaccines, suggesting a possible predictive biomarker and patient enrichment strategy. But in addition, characterization of these subsets may pave the way for catering therapeutic interventions toward the biologic features of the tumor in individual patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Tumor
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Innate Immunity
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Adaptive Immunity
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Escape
dc.subject.classification
Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-30T13:42:55Z
dc.journal.volume
23
dc.journal.number
2
dc.journal.pagination
286-292
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Gajewski, Thomas F.. University Of Chicago; Estados Unidos
dc.description.fil
Fil: Fuertes, Mercedes Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. University Of Chicago; Estados Unidos
dc.description.fil
Fil: Spaapen, Robbert. University Of Chicago; Estados Unidos
dc.description.fil
Fil: Zheng, Yan. University Of Chicago; Estados Unidos
dc.description.fil
Fil: Kline, Justin. University Of Chicago; Estados Unidos
dc.journal.title
Current Opinion In Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VS1-51SK6MC-2-1&_cdi=6249&_user=7223143&_pii=S0952791510002013&_origin=&_coverDate=04%2F30%2F2011&_sk=999769997&view=c&wchp=dGLzVlb-zSkWb&md5=3ffd90dfd53a9025e2d40ce2ff9212a9&ie=/sdarticle.pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.coi.2010.11.013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070788/
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